蝉蜕对大鼠血液流变学影响的实验研究  

The effect of periostracum cicadae on hemorheology in rats

作　　者：刘善庭[1] 李建美[1] 王立赞[1] 王清[1] 梁玉记[1] 朱凡河[1] 李军[1] 齐汝霞[1] 于江[1] 林丽文[1] 

机构地区：[1]济宁医学院,山东济宁272013

出　　处：《中医药学报》2004年第3期56-58,共3页Acta Chinese Medicine and Pharmacology

摘　　要：目的 :观察中药蝉蜕对高脂血症大鼠血液流变学的影响。方法 :Wistar大鼠随机分 5组 ,其中高脂加蝉蜕水提液组采用高脂喂养 ,同时给予蝉蜕水提液灌胃 ,连续 9天 ,末次给药后 1小时取血检测血液流变各项指标并进行统计学处理。结果 :高脂喂养的大鼠血清总胆固醇及甘油三酶水平明显升高 ,全血和血浆粘度、体外血栓形成、红细胞聚集指数显著增加 ;蝉蜕水提液对正常大鼠的血液流变学无显著影响 ,对高脂喂养的大鼠能显著降低其全血和血浆粘度、体外血栓形成、红细胞聚集指数、血清甘油三酯及总胆固醇水平。结论 :蝉蜕具有显著改善高脂血症病理状态下的血液流变学作用。The effect of periostracum cicadae on hemorheology in rats wasstudied.Water-extracted substance from PeriostracuIIl cicadaewas infused into the stomach of Wister rats feeded with hyperlipid for 9 days. Blood samples were taken andhemorheeological indexes were determined.The results demonstrated that periostracum cicadae markedly decreased blood viscosity,thrombosis in vitro, serum glycerinate and cholesterol contents,and red blood cell aggregation.As for the mechanism of periostracum cicadae on improving hemorheology,it remains to be in vestigated further.

关 键 词：蝉蜕 血液流变学 大鼠 水提液 高脂喂养 红细胞聚集指数 体外血栓形成 甘油 降低 给药 

分 类 号：R285.5[医药卫生—中药学] R282[医药卫生—中医学]