高脂血症患者血尿β_2微球蛋白及尿渗透压观察  

Observation of β_2—Microglobulin and Urine Osmotic Pressure in the Patient with Hyperlipidemia

作　　者：刘惠[1] 韩红[2] 阮敬华[1] 黄洁[1] 白云凯[1] 樊均明[1] 肖桦[1] 

机构地区：[1]昆明医学院肾脏内科 [2]昆明医学院病理生理教研室

出　　处：《昆明医学院学报》1993年第1期34-36,共3页Journal of Kunming Medical College

摘　　要：作者探讨了45岁以上74例高脂血症患者和38例正常人的血尿β_2微球蛋白和尿渗透压的差异。观察到45-49岁及50岁以上的高脂血症患者血中的β_2微球蛋白分别升高了44.7％和38.6％(P<0.05),尿β_2微球蛋白没有明显改变;而尿渗透压则分别降低7.3％和15.1％(P<0.05)。这些结果表明,高脂血症患者可能有肾小球滤过功能和远端肾小管重吸收功能的减退,“脂质肾毒性”在肾脏衰老中起一定作用。The purpose of this study was to investigate β_2—microglobulin and urine osmotic pres- sure of 74 patients with hyperlipidemia and 38 normal subjects over 45 years of age. There were significant increase in blood β_2—microglobuhlin and decrease in urine osmotic pressure in the patients with hyperlipidemia. But there was no significant alteration in urine β_2— microglobulin. These results seemed to indicate that hyperlipidemia could lead to the injury of glomerular filtration and the reabsorption of distal tubules. Lipidtoxic effect might play an important role in the renal injury in the patient with hyperlipidemia.

关 键 词：高血脂病 微球蛋白 尿渗透压 肾脏 

分 类 号：R589.202[医药卫生—内分泌]