镍-膦配合物催化偶联反应和多联苯的合成  

Cross-coupling Reaction of Grignard Reagent with Aryl Halides by Using the Nickle Phosphine as Catalyst and the Synthesis of Multiphenyls

作　　者：丘昌隆[1] 蓝志银 

机构地区：[1]兰州大学化学系,兰州730000

出　　处：《兰州大学学报（自然科学版）》1993年第4期176-178,共3页Journal of Lanzhou University(Natural Sciences)

摘　　要：利用镍－膦络合物Ｎｉ（Ｐｐｈ３）２Ｃｌ２，Ｎｉ（ＰＢｕ＾ｎ３）２Ｃｌ２，ＮｉＣｌ２·ｄｐｐｅ，ＮｉＣｌ２·ｄｐｐｐ以及无膦配体的二氯化镍作为催化剂，能有效地促进苯基格氏试剂和苯基卤化物的交叉偶联反应，方便地制取三、四、五联苯作为液晶及有机闪烁剂的原料。文中着重对无膦酸体无水氯化镍的作用范围和及应用机理进行了讨论。The use of nickle phosphine complexes Ni(Pph_3)_2Cl_2,NiCl_2·(PBu_3)_2,NiCl_2(dppe),NiCl_2(dppp)and anhydrous NiCl_2,(free of ligand)has effectively promotedthe cross-couplig reaction of Grignard reagent with phenyl halides.This reaction can beeasily applied to the synthesis of p-terphenyl,p-tetraphenyl and p-quinquephenyl whichcan be used as the materials of liquid crystal and scintillation.We have also found thatthe free ligand anhydrous NiCl_2 catalysed the reaction of phMgX with phenyl halides justas the NiCl_2 dppp catalyst does.A mechanism of this reaction has also been proposed.

关 键 词：氯化镍 多联苯 催化 镍-膦络合物 

分 类 号：O625.13[理学—有机化学]