聚合物负载的相转移催化剂作用下的潜手性酮不对称还原  

Asymmetric Borohydride Reduction of Prochiral Phenyl Ketones Catalyzed by Polymer-supported Alkaloids under Two-phase Condition

作　　者：金鑫[1] 张政朴[1] 李贺先[1] 何炳林[1] 

机构地区：[1]南开大学高分子化学研究所,天津300071

出　　处：《离子交换与吸附》1993年第4期300-304,共5页Ion Exchange and Adsorption

摘　　要：本文在苯乙烯—二乙烯苯共聚物上负载了奎宁、辛可宁、D—(一)—麻黄碱制备胺盐型相转移催化剂,对一系列苯基烷基潜手性酮的硼氢化还原反应进行了不对称催化。研究了负载不同生物碱的催化剂,不同的潜手性酮,不同的反应温度及不同的有机介质对反应的化学收率及光学产率的影响,并对反应机理进行了一定的探讨。Polymer-supported quinine, cinchonine, and D-(-)-ephedrine were prepared. Catalyzed by them under two-phase condition, a series of prochiral phenyl ketones were reduced by sodium borohydride. The influences of catalysts, prochiral ketones, temperature and organic solvents on the yields and optical purities of products were studied.

关 键 词：负载 高聚物 相转移催化剂 酮 还原 

分 类 号：O622.4[理学—有机化学]