新生期给予己烯雌酚对7周龄雌性BALB/c小鼠胸腺内雌激素受体的影响  

Effect of administered diethylstilbestrol on estrogen receptors in the thymus of 7-week old female BalB/c mice in neonatal period

作　　者：孙申[1] 卫兰[2] 宋清坤[3] 马强[2] 张京[2] 

机构地区：[1]徐州医学院组织胚胎学教研室,江苏徐州221002 [2]北京大学医学部基础医学院组织胚胎学教研室,北京100083 [3]北京大学医学部预防医学系

出　　处：《徐州医学院学报》2004年第5期377-379,共3页Acta Academiae Medicinae Xuzhou

基　　金：教育部 985资助课题

摘　　要：目的　探讨己烯雌酚对BALB c小鼠胸腺内雌激素受体水平的影响。方法　新生小鼠分为实验组与对照组 ,连续 5天皮下注射己烯雌酚 ,7周后取其胸腺进行雌激素受体免疫组织化学反应及图像分析。结果　己烯雌酚可以提高实验组小鼠胸腺内雌激素受体水平 ,2组间有显著性差异。结论　雌激素对胸腺的作用主要是通过雌激素受体来进行 ,新生期接触雌激素对胸腺内雌激素受体水平的影响会持续到成年期。Objective To investigate the changes of estrogen receptors (ER) in thymus of 7-week old female BalB/c mice after having been treated with diethylstilbestrol (DES) in their neonatal period. Methods Neonatal female BALB/c mice were injected DES hypo 5 days after birth. They were killed on the 49th days to study the changes in ER by immunohistological technique. Results It was found that the administered DES increased the level of estrogen receptor in thymus. Conclusion Estrogen acts on thymus mainly through its receptors, and even the neonatal contact of estrogen will later influence the whole life of the mice.

关 键 词：新生期 己烯雌酚 BALB/C 雌性小鼠 胸腺 雌激素受体 

分 类 号：R977.12[医药卫生—药品]