糖皮质激素受体在鼻息肉组织中的表达与意义  

EXPRESSION AND SIGNIFICANCE OF GLUCOCORTCOID RECEPTORS IN NASAL POLYPS

作　　者：林海[1] 李湘平[2] 梁勇[2] 宋江顺[2] 何海棠[3] 张明霞[3] 

机构地区：[1]福州总医院耳鼻喉科 [2]第一军医大学南方医院耳鼻喉科 [3]第一军医大学南方医院感染内科实验室

出　　处：《福州总医院学报》2004年第4期264-266,303,共4页Journal of Fuzhou General Hospital

摘　　要：目的:观察糖皮质激素受体在鼻息肉组织中的分布、表达,探讨糖皮质激素治疗鼻息肉的合理性及机理。方法:利用免疫组化染色以及逆转录-聚合酶链反应(RT-PCR反应)检测13例鼻息肉病、22例一般鼻息肉及23例正常下鼻甲组织的糖皮质激素受体。结果:糖皮质激素受体主要分布于鼻息肉表面上皮粘膜、粘膜下腺体、血管内皮细胞以及炎症细胞的胞浆与脆核内。糖皮质激素受体在鼻息肉病组、一般鼻息肉组与下鼻甲组中的表达无显著差异。结论:糖皮质激素受体通过与糠皮质激素受体相结合而发挥抗炎作用,糖皮质激素受体在鼻息肉病与一般鼻息肉组中的一致性表达提示糠皮质激素是治疗鼻息肉病及鼻息肉的一种可靠方法。Objective: To study the expression and distribution of glucocortiooid receptors (GR) in nasal polyps and clarify its reliability and mechanism of glucocorticoids treatment in the nasal polyps. Method: Immunohistochernistry method and reverse transcription - polymerase chain reaction (RT- PCR) method were used to determine glucocorticoid receptors expression in 13 nasal polyposis, 22 nasal polyps and inferior turbinates (23 normal controlled group) .Results: In nasal polyps, GR labeling was associated with the cytoplasm and nucleus of surface mucosa, submucosal glands, endothelial cells, and inflammatory cells. GR was labeled in both tissues and there no significant differences of GR expression levels in nasal polyposis, nasal polyps and normal controls.Conclusion: Glucocorticoids may exert their anti- inflammatory effects through an interaction of glucocorticoid receptors, Glucocorticoids may be a reliable method to treat nasal polyposis and nasal polyps.

关 键 词：糖皮质激素受体 鼻息肉 基因表达 逆转录-聚合酶链反应 免疫组织化学 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]