环氧合酶-2对鼻息肉炎症形成的作用研究与探讨  

EXPRESSION AND SIGNIFICANCE OF CYCLOOXYGENASE-2 IN NASAL POLYPS

作　　者：林海[1] 李湘平[2] 梁勇[2] 宋江顺[2] 何海棠[3] 张明霞[3] 

机构地区：[1]福州总医院耳鼻喉科 [2]第一军医大学南方医院耳鼻喉科 [3]第一军医大学南方医院感染内科实验室

出　　处：《福州总医院学报》2004年第4期270-273,共4页Journal of Fuzhou General Hospital

摘　　要：目的:检测研究环氧合酶-2在鼻息肉病、一般鼻息肉组织中的表达水平及其分布情况,深入认识鼻息肉炎性发病机制。方法:利用免疫组化染色以及逆转录-聚合链反应(RT-PCR反应)检测13例鼻息肉病、22例一般鼻息肉及23例下鼻甲标本的环氧合酶-2的表达。结果:环氧合酶-2主要分布于鼻息肉粘膜上皮、粘膜下腺体、血管内皮细胞以及炎性细胞的胞浆或胞膜,呈胞浆膜型及包涵体型。鼻息肉病组织中COX-2表达明显高于下鼻甲,又高于一股鼻息肉。结论:鼻息肉病组织中COX-2表达明显增高,鼻息肉以及鼻息肉病的发病过程中有前列腺素参与。Objective: To study the expression and ditribution of cyclcoxygenase-2 in nasal polyps. Method: Immunohis-tochemistry method and reverse transcription - polymerase chain reaction (RT-PCR) method were used to determine cyclooxyge-nase - 2 expresion in 13 nasal polyposis, 22 nasal polyps and inferior turbinates (23 normal controlled group) . Results: COX-2 labeling was seen in the cytoplasm and cytomembrane of surface mucosa, submucosal glands, the vascular wall and inflammatory cells in nasal polyposis and nasal polyps. COX-2 expression is remarkably upregulated in nasal polyposis compared to nasal polyps and normal controlled gropu.Conclusion: The results showed that nasal polyposis was a chronic reactive inflammatory disease on which prostaglandins play an important role.

关 键 词：环氧合酶-2 鼻息肉 炎症 前列腺素 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]