甲壳素对猪传染性胃肠炎免疫调节作用的研究  

THE IMMUNOMODULATION EFFECT OF CHITIN ON TRANSMISSIBLE GA STROENTERITIS OF PIGS

作　　者：邹勇[1] 唐永兰[1] 苏万国[1] 钱永清[1] 何锡忠[1] 

机构地区：[1]上海市农业科学院畜牧兽医研究所,上海201106

出　　处：《上海农业学报》2004年第4期128-129,共2页Acta Agriculturae Shanghai

基　　金：上海市农业科学院青年基金项目。

摘　　要：研究了甲壳素对猪传染性胃肠炎疫苗的免疫调节作用 ;用浓碱法处理甲壳素可获得吸附能力强的佐剂 ,但物理性状不适合用于疫苗佐剂 ;壳聚糖可用作制备具有良好水溶性的疫苗佐剂 ,经与白油和蜂胶等佐剂比较 ,表明该佐剂对猪传染性胃肠炎具有一定的免疫调节作用。即 4种佐剂的疫苗在免疫后 14d ,壳聚糖疫苗组抗体效价显著高于其它组 ;免疫后 30～ 12 0d油乳剂疫苗组抗体效价显著高于其它组。The immunomodulation effects of different ramificati ons of chitin were studied. The adjuvant with great adsorption capacity could be obtained through treating chitin with concentrated alkali, but its physical pro perty was not suitable for vaccine.An adjuvant with good water solubility can be prepared with chitosan. This adjuvant had a certain immunomodulation effect on transmissible gastroenteritis of pigs compared with such adjuvants as propolis a nd mineral oil. The experimental results showed that the titer of chitosan group was significantly higher than those of other groups at 14 days after immunizati on and the titer of oil emulsion group was significantly higher than those of ot her groups between 30～120 days after immunization.

关 键 词：甲壳素 猪 传染性胃肠炎 免疫调节 壳聚糖 

分 类 号：S858.28[农业科学—临床兽医学]