Association of HLA-B Alleles With Human Immunodeficiency Virus Type 1 Infection in the Yi Ethnic Group in Sichuan Province  

作　　者：MING-YANXU KUN-XUEHONG XIAO-LINGDENG JUNLI HONGPENG Yu-HuARUAN GUAN-MINGQIN HUIXING XIAO-HUXU ANDYI-MINGSHAO 

机构地区：[1]DivisionofResearchonVirologyandImmunology,NationalCenterforSTD／AIDSControlandPrevention,Beijing100050,China [2]DepartmentofForensicMedicine,ShantouUniversityMedicalCollege,Shantou515041,Guangdong,China [3]SichuanProvincialCenterforDiseaseControlandPrevention,Chengdu61003,Sichuan,China

出　　处：《Biomedical and Environmental Sciences》2004年第2期203-208,共6页生物医学与环境科学（英文版）

基　　金：This work was supported by the Special Funds for Major State Basic Research Program (973) of China (No.G1999054107) ; the National Key Technologies R & D Program of China during the 15th Five-years Plan Period (No. 2001BA705B02)

摘　　要：Objective To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection. Methods One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP. Results The frequency of alleles B*07, B*35, and B*46 were increased in HTV-1 -positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects. Conclusion HLA-B*46 may be associated with its susceptibility to HIV-1 infections.Objective To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection. Methods One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP. Results The frequency of alleles B*07, B*35, and B*46 were increased in HTV-1 -positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects. Conclusion HLA-B*46 may be associated with its susceptibility to HIV-1 infections.

关 键 词：HIV infections HLA-B alleles ASSOCIATION 

分 类 号：R512.91[医药卫生—内科学]