甲磺酸加替沙星片治疗急性细菌性感染的细菌学疗效  

Bacteriological Efficacy of Gatifloxacin Methanesulfonate Tablet on Acute Bacterial Infections

作　　者：崔俊昌[1] 王睿[1] 裴斐[1] 刘庆锋[1] 余秉翔[1] 段蕴铀[2] 高和[3] 陈萍[4] 王选锭[5] 张健鹏[6] 梁蓓蓓[1] 方翼[1] 柴栋[1] 刘又宁[1] 

机构地区：[1]解放军总医院 [2]海军总医院北京100037 [3]空军总医院 [4]沈阳军区总医院 [5]浙江大学第二附属医院 [6]武警总医院

出　　处：《中华医院感染学杂志》2004年第8期920-923,共4页Chinese Journal of Nosocomiology

摘　　要：目的　评价甲磺酸加替沙星片治疗急性细菌性感染疾病的细菌学疗效。方法　以盐酸左氧氟沙星片为对照药 ,采用多中心随机盲法阳性对照平行试验设计方法 ,评价甲磺酸加替沙星片治疗急性细菌性感染的细菌学疗效。结果　甲磺酸加替沙星片组和盐酸左氧氟沙星片组细菌分离阳性率分别为 77 4 2 %和 80 99% ;两组细菌清除率分别为 97 92 %和 97 96 % ;对不同致病菌感染有效率分别为 83 33%～ 10 0 %和 80 %～ 10 0 % ;以上结果两组差异无统计学意义 ;纸片药敏试验结果表明加替沙星、左氧氟沙星、氧氟沙星、环丙沙星和司帕沙星的细菌敏感率分别为 93 81%、93 30 %、91 2 4 %、84 5 4 %和 87 11% ;从MIC90 结果看 ,加替沙星对多数致病菌的抗菌活性略强于左氧氟沙星。结论　甲磺酸加替沙星片具有良好的细菌学疗效。OBJECTIVE To analyze the bacteriological efficacy of gatifloxacin methanesulfonate tablet on acute bacterial infections. METHODS Levofloxacin hydrochloride tablet was used as a control drug and a randomized controlled multicenter clinical trial was conducted to evaluate the bacteriological efficacy of gatifloxacin methanesulfonate tablet on acute bacterial infections. RESULTS The bacterial positive rates in the gatifloxacin group and the levofloxacin group were 77.42 % and 80.99%, respectively, and the bacterial clearance rates were 97.92% and 97.96%, respectively. The efficacy rates of two groups against different bacterial infections were 83.33-100% and 80-100%, respectively. The differences of the results were not statistically significant (P>0.05) . The susceptible rates of bacterial isolates to gatifloxacin,levofloxacin,ofloxacin, ciprofloxacin and sparfloxacin were 93.81%, 93.30%, 91.24%, 84.54% and 87.11%, respectively. The antibacterial activity of gatifloxacin was higher than that of levofloxacin from the results of MIC 90 . CONCLUSIONS Gatifloxacin methanesulfonate tablet has good bacteriological efficacy.

关 键 词：甲磺酸加替沙星片 盐酸左氧氟沙星片 感染 细菌学疗效 

分 类 号：R978.11[医药卫生—药品]