单克隆抗体对日本血吸虫尾蚴钻穿小鼠皮肤能力的影响  

THE EFFECT OF MONOCLONAL ANTIBODY ON THE SKIN PENETRATING ABILITY OF THE CERCARIAE OF SCHISTOSOMA JAPONICUM IN MICE

作　　者：叶萍[1] 田锷[1] 林邦发[1] 石耀军[1] 朱顺海[1] 林矫矫[1] 钟志萍[1] 

机构地区：[1]中国农科院上海家畜寄生虫病研究所

出　　处：《中国兽医寄生虫病》1993年第1期30-32,共3页Chinese Journal of Veterinary Parasitology

摘　　要：用抗日本血吸虫单克隆抗体,在室温下与血吸虫尾蚴作用90分钟。将尾蚴分别经腹部皮肤和腹腔注射感染昆明系小鼠,4周后剖杀集虫。实验结果表明。经单克隆抗体(McAb)处理后,腹腔注射组的载虫数明显高于腹部皮肤感染组(P<0.01)。从而说明,高特异性的单克隆抗体处理能够影响尾蚴钻穿小鼠腹部皮肤的能力。Mice of kunming strain wera infected with cercariae of Schistosoma japonicum having been treated in vitro for 9 minutes with anti-S.japonicum monoclonal antibody (McAb) and autopsied after 4 weeks for worm recovery. The results revealed that the worm burden of the intraperi- toneally infected mice group (i.p.) is significantly higher than that of the percutaneously infec- ted mice group (p.c.)(p<0.01).This experiment showcd that the skin penetrating ability of the cercariae might be affected by their previous in vitro treatment with a McAb of class IgM produced in our laboratory.

关 键 词：单克隆抗体 日本血吸虫 尾蚴 小鼠 钻透能力 

分 类 号：S852.735[农业科学—基础兽医学] S852.43[农业科学—兽医学]