SARS患者预后骨密度和骨结构变化的现况研究  

Cross-sectional study of density and structure of bone in SARS patients′ conva lescence

作　　者：高宏生[1] 惠武利[1] 王世鑫[2] 李玉明[2] 王立[2] 王中军[1] 

机构地区：[1]武警医学院流行病学教研室 [2]武警医学院附属医院,天津300162

出　　处：《武警医学院学报》2005年第1期14-16,共3页Acta Academiae Medicinae CPAPF

摘　　要：【目的】探讨SARS患者预后骨密度和骨结构变化的影响因素。【方法】利用病历资料调查患者治疗期间的糖皮质激素用法 ,在患者出院 3m后应用间接免疫荧光法 (IFA)测定血清特异抗体IgG ,应用定量超声(QUS)测定患者的骨密度和骨结构变化情况 ,统计分析采用协方差分析。【结果】 4 0例SARS患者中出现骨质疏松 2例 ,骨密度减低 30例 ,正常 8例。骨密度的影响因素有年龄、冲击疗法和糖皮质激素总量 ;骨结构和骨弹性的影响因素有冲击疗法、冲击疗法持续的天数 ;血清特异抗体IgG与患者预后出现的骨质疏松在统计学上无联系。【结论】SARS患者骨质破坏的发病率很高 ,骨密度的减低、骨结构的变化主要与年龄、激素剂量有关 ,和SARS病毒可能没有关系。To explore the factors affecting dens ity and structure of bone in SARS patient′s convalescence.The usage of corticosteroids in SARS patient′s therapy w as reviewed in case history. The antibody IgG in serum was assessed with the way s of IFA(indirect immunofluorescent antibody), the density and fabric of bone we re measured with QUS (quantitative ultrasound) on the third month after SARS pat ients discharged from hospital. Of 40 SARS patients, there were 2 osteoporosis cases, 30 bone density decrement cases. The bone density of the patients was influenced b y the factors including age, the dosage summation, and the impultional therapeut ics. The fabric and flexibility of bone were influenced by the factors including implosion therapy. There were no relations between the serum antibody IgG and t he bone quality′s variety in statistics.[Conclusion]The SARS patients have the higher prevalence rates of osteoporosis than the overall population. The transformation of bone quality wha t couldn′t be affected by the SARS virus is correlated with age, the dosage of corticosteroids.

关 键 词：SARS 糖皮质激素 抗体IGG 骨密度 

分 类 号：R681[医药卫生—骨科学]