胰腺多层螺旋CT灌注研究  

Multisection dynamic CT perfusion for normal and tumorous pancreas

作　　者：赵心明[1] 周纯武[1] 吴宁[1] 罗德红[1] 黄遥[1] 王建卫[1] 孙伟[1] 梁颖[1] 

机构地区：[1]中国医学科学院肿瘤医院影像诊断科,北京100021

出　　处：《中华放射学杂志》2003年第9期845-849,共5页Chinese Journal of Radiology

摘　　要：目的　使用多层螺旋CT的肿瘤灌注软件 ,测量和评价正常胰腺和胰腺癌的CT灌注情况。方法　采用GELightspeedUltra多层螺旋CT的电影模式 ( 1s/周 ) ,5mm层厚 ,4层 ,12 0kV ,60mA ;采用高压注射器注射非离子型对比剂 50ml( 3 0 0mgI/ml) ,流率 3 5ml/s ,延迟 5s ,数据采集 45s。在SunUltraAW 4 0工作站使用Perfusion 2 (GE公司 )软件包 (去卷积算法 ) ,分别测量 3 7例正常胰腺和 3 7例胰腺癌及 3例无功能胰岛细胞瘤的血流量 (BF)、血容量 (BV)、平均通过时间 (MTT)和表面通透性(PS)的平均值 ,并进行统计学分析。结果　正常胰腺组的BF、BV、MTT和PS的平均值分别为 ( 3 3 86 2± 1596 1)ml·min- 1·kg- 1、( 2 67 3± 13 0 2 )ml·kg- 1、( 6 59± 2 59)s、( 2 88 2± 2 0 3 9)ml·min- 1·kg- 1。胰腺癌组的BF、BV、MTT和PS的平均值分别为 ( 2 3 2 3 1± 1841 2 )ml·min- 1·kg- 1、( 189 7± 160 6)ml·kg- 1、( 7 93± 3 92 )s、( 4 57 2± 2 61 6)ml·min- 1·kg- 1。胰腺癌组和正常胰腺组的BF、BV和PS的平均值差异具有显著性意义 (P值分别为 0 0 1、0 0 2 5和 0 0 0 3 )。胰腺癌和正常组织的MTT的平均值差异无显著性意义 (P =0 0 87)。结论　多层螺旋CT的胰腺灌注图像和数值比较容易获得。Objective To measure and assess CT perfusion for normal and cancerous pancreas by using multisection dynamic CT with tumor perfusion software package Methods The multisection dynamic CT perfusion series was performed for pancreatic perfusion with cine mode (1 s per rotation) on a multisection CT scanner (Lightspeed Ultra, GE, Waukesha, WI, USA), 4×5 mm collimation, 120 kV, 60 mA Contrast injection was done by using 50 ml nonionic contrast agent (300 mgI/ml), at a flow rate of 3 5 ml/s with a power injector, and 5 seconds delay, and data acquisition lasted for 45 seconds The mean BF, BV, MTT, and PS were measured and statistically analyzed in patients with normal pancreas ( n =37), pancreatic carcinoma ( n =37), and none-functioning islet cell tumor ( n =3) proven by clinic and pathology, respectively, on a Sun Ultra AW4 0 workstation using Perfusion 2 software package (GE) with deconvolution method Results The mean BF, BV, MTT, and PS in normal pancreas tissue were (3 386 2± 1 596 1)ml·min -1 ·kg -1 , (267 3±130 2)ml·kg -1 , 6 59±2 59 s, (288 2±203 9)ml·min -1 ·kg -1 , respectively The mean BF, BV, MTT, and PS in pancreatic carcinoma were (2 323 1± 1 841 2) m l·min -1 ·kg -1 , (189 7±160 6)ml·kg -1 , 7 93±3 92 s, (457 2±261 6)ml·min -1 ·kg -1 , respectively The mean BF, BV, and PS between pancreatic carcinoma and normal pancreas were statistically significant ( P =0 01,0 025, and 0 003) However, the mean MTT between pancreatic carcinoma and normal pancreas was not statistically significant ( P =0 087) Conclusion The pancreatic perfusion with multisection CT can be readily obtained The mean BF, BV, and PS between pancreatic carcinoma and normal pancreas were statistically significant

关 键 词：胰腺癌 正常 多层螺旋CT BV 灌注 MTT BF 工作站 软件包 算法 

分 类 号：R816.5[医药卫生—放射医学]