冠心病、高心病患者血浆纤维结合蛋白的测定及其意义  

Plasma fibronectin level in coronary and hypertensive heart disease

作　　者：黄灿成[1] 徐敏[1] 

机构地区：[1]湖南医科大学附二院内科,410011

出　　处：《临床心血管病杂志》1993年第5期270-271,共2页Journal of Clinical Cardiology

摘　　要：对37例冠心病、18例高心病及31例正常人的血浆纤维结合蛋白(Fn)进行测定,结果表明冠心病和高心病患者血浆Fn明显低于正常人(P<0.001),冠心病患者中稳定型心绞痛(SA)者降低更明显,急性心肌梗塞者较SA者增高但仍低于正常人,不稳定型心绞痛者的Fn略大于正常值。提示Fn可作为评估冠心病演变的一项指标。This paper determined plasma fibronectin(Fn)level in 31 cases of normal persons, 37 cases of coronary heart disease(CHD) and 18 cases of hypertensive heart disease(HHD). We observed that the plasma levels of Fn in CHD and HHD patients were significantly less than that in normal controls (P<0. 001). The lowerst Fn was seen in stable angina (SA) cases of the CHD group. Fn was higher in AMI cases than SA cases,but it was still significantly less than in the normal controls. In unstable angina cases,the Fn was even higher than in normal controls,but the difference was not significant. The results suggested that the alterations of Fn in CHD and HHD may reflect the nonspecific defense abilities against arteriosclerosis and consecutive monitoring of Fn may be helpful in predicting the outcome of CHD patients.

关 键 词：纤维结合蛋白 冠心病 高血压 

分 类 号：R541.404[医药卫生—心血管疾病]