血栓闭塞性脉管炎的病理形态学观察和免疫病理学研究  

Histopathologyical and Immunopathological Study of Thromboangiitis Obliterans

作　　者：聂明[1] 王黎[1] 朱海青[1] 赖尧基[2] 夏友祥 须大卫 

机构地区：[1]江苏省中医院病理科,南京210029 [2]江苏省中医药研究所,南京210037

出　　处：《临床与实验病理学杂志》1993年第2期123-125,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：本文对45例血栓闭塞性脉管炎(TAO)截肢标本中血管分节段进行了病理组织学观察,见病变血管示慢性非特异性炎症改变,在活动期,以渗出为主,见大量淋巴细胞浸润,并伴有血管内膜受损;以后出现继发性病变,包括血栓形成、机化、管腔闭塞。对部分新鲜标本的血管进行了免疫病理学研究,包括免疫荧光和免疫酶标法,在活动性炎的血管壁上见有免疫球蛋白(IgM、IgG、IgA)和补体(C_(1q)、C_3)存在,说明局部有免疫复合物沉积。以上结果提示:TAO的发生与免疫有关,是一种自身免疫性疾病。There were 45 cases thromboangiitis obliterans(TAO)patients after amputation opera-tion.The histopathology study was done on the stumps.They all showed chronic nonspecific vasculitis.At early stage of disease,the main changes were exudation,with endangium injure.With developing ofdisease,lesions showed thromb form and organization.The study of immunofluorescence and immu-noenzyme(ABC & PAP)in some samples showed that the immunoglobulin(IgM,IgG,&.PAP)andcomplement(C_(lq)& C_3)could be seen on the endangium.These are the deposition of immunocoplex.The results surggest that TAO is one of the autoimmunodiseases.

关 键 词：免疫组织化学 自身免疫病 脉管炎 

分 类 号：R654.402[医药卫生—外科学]