分子印迹整体柱分离手性氨基酸衍生物的色谱研究  

Chromatographic Properties for Enantiomeric Separation of Amino Acid Derivatives on the Molecularly Imprinted Monoliths

作　　者：黄晓冬 陈学国 欧俊杰 唐守万 孔亮 邹汉法 

机构地区：[1]National Chromatographic Research & Analysis Center, Dalian Institute of Chemical Physics,The Chinese Academy of Sciences, Dalian 116011, China

出　　处：《色谱》2004年第4期338-345,共8页Chinese Journal of Chromatography

基　　金：国家自然科学基金，国家重点基础研究发展计划(973计划)，国家高技术研究发展计划(863计划)，the Knowledge Innovation program of Dalian Institute of Chemical Physics

摘　　要：Since their introduction in 1992 by Fréchet and Svec[1], monolithic supports as stationary phases in high performance liquid chromatography (HPLC) and capillary electrochromatography (CEC) have gained significant interest due to a number of unique properties. Their ease of preparation, high reproducibility, versatile surface chemistry and fast mass transport are advantageous in a variety of applications[2-4]. Separations in diverse chromatographic modes have been performed in either HPLC or CEC, showing their strong point for high-speed separations of biological and synthetic molecules[5-12]. Although a number of papers have been reported on the application of monolithic supports as chiral stationary phases in CEC and pressure-assisted capillary electrochromatography (p-CEC)[13-19], few reports have so far been published on chiral monolithic stationary phases for liquid chromatography[20].

关 键 词：色谱性质 手性分离 氨基酸衍生物 分子印迹 单片固定相 热力学 高效液相色谱 毛细管电动色谱 

分 类 号：O623.736[理学—有机化学] O657.7[理学—化学]