中国成都扩张型心肌病患者醛固酮合酶遗传多态性与左心室结构和功能关系研究  

Study on Association Between Aldosterone Synthase Gene Polymorphism and the Left Ventricular Structure and Function of Patients with Dilated Cardiomyopathy in China

作　　者：饶莉[1] 周斌[2] 王斌[1] 王宇平[1] 李英碧[2] 张林[2] 

机构地区：[1]四川大学华西医院心内科,成都610041 [2]四川大学基础医学与法医学院物证学教研室

出　　处：《四川大学学报（医学版）》2004年第6期809-811,共3页Journal of Sichuan University(Medical Sciences)

基　　金：四川省科技厅应用基础项目 ( 0 2 SY0 2 9-13 2 );四川省杰出青年基金 ( 2 0 0 1-2 )资助

摘　　要：目的　探讨扩张型心肌病患者醛固酮合酶 CYP11B2基因 - 344 C/T遗传多态性与左心室结构和功能的关系。方法　临床收集 89例中国成都地区扩张型心肌病患者外周静脉血样本 ,采用聚合酶链反应 -限制性片段长度多态性技术 (PCR- RFL P)检测基因型并分为 TT、TC、CC和 TT+CC四组 ,经胸超声心动图技术测量左心室结构和功能指标 ,回顾性的对分组后的各种数据进行收集和统计。结果　扩张型心肌病患者左室内径、心肌质量及左室射血分数在各基因型组之间无明显差异 (P>0 .0 5 )。结论　小样本研究表明醛固酮合酶 CYP11B2基因遗传多态性与扩张型心肌病患者左室结构和功能无明显相关。Objective To investigate the association between a -344 C/T polymorphism of aldosterone synthase gene (CYP11B2) and the left ventricular structure and function of patients with dilated cardiomyopathy(DCM) in China. Methods Eighty-nine patients with DCM were genotyped by PCR-RFLP, and were divided into TT, TC, CC and TT+CC four groups by their genotypes, respectively. Left ventricular structure and function were assessed with echocardiography. Results There was no significant difference between four groups in left ventricular diameters, mass and ejection fraction in patients with DCM. Conclusion The data were not in favor of a significant association between the aldosterone synthase gene CYP11B2 and the left ventricular structure and function in patients with DCM.

关 键 词：扩张型心肌病 醛固酮合酶 遗传多态性 左心室 

分 类 号：R542.22[医药卫生—心血管疾病]