同位素质谱法检测尿中雄烯二酮代谢物  

作　　者：王静竹[1] 吴侔天[1] 张亦农[1] 刘欣[1] 杨志勇[1] 

机构地区：[1]国家体育总局运动医学研究所，北京100029

出　　处：《质谱学报》2004年第B10期201-202,共2页Journal of Chinese Mass Spectrometry Society

摘　　要：A method was established for measuring the isotope ratios of ^13C to ^12C of the metabolites of androstenedione in urine. The source of these metabolites could be distinguished. The metabolism time of the steroids could be detected with this method. Preliminary separation of endogenous anabolic androgenic steroids could be achieved using enzymolysis, HPLC. The source of the metabolites of androstenedione could be detected byt heirδvalues with gas chromatography-combustion-isotope ratio mass spectrometry. The results showed that theδvalues of some metabolites of androstenedione reduced after the administration of androstenedione preparation. In these cases the data hinted that exogenous anabolic androgenic steroids were administrated. The source of metabolites of androstenedione in urine could be detected by measuring theirδvalues with this method in some period.

关 键 词：同位素质谱 尿 雄烯二酮 代谢物 内源性类固醇激素 

分 类 号：O629.2[理学—有机化学] R977.1[理学—化学]