高效液相色谱检测器-飞行时间质谱的研制  

作　　者：贾韦韬[1] 徐国宾[1] 姚均[1] 何坚[1] 周振[1] 杨芃原[1] 

机构地区：[1]复旦大学化学系，上海200433

出　　处：《质谱学报》2004年第B10期209-210,共2页Journal of Chinese Mass Spectrometry Society

摘　　要：Time-of-flight mass spectrometry (TOF-MS) is widely used in protein chemistry and proteomics research due to its high sensitivity , resolution and accuracy. Recently we have developed two Q-TOF-MS analytical systems titled as “ESI-TOF-MS detector of HPLC”, which have promising features and arrive at the coordinative level compared with the congener overseas production. The ESI-Orthogonal Acceleration-Reflecting-TOF mass spectrometry can detect the lysozyme sample concentration below 1 pmol/μL under the optimized conditions. The mass range of these instruments is from 50 to 6000dahon with a general ESI interface to the HPLC. The optimal mass resolution exceeds 6000(FWHM)and the signal/noise ratio of Reserpine (10 ng/L) is greater than 100.

关 键 词：高效液相色谱检测器 飞行时间质谱仪 研制 电喷雾质谱检测器 

分 类 号：O657.63[理学—分析化学] TH843[理学—化学]