牛血清蛋白单层膜诱导形成网状结构的羟基磷灰石  

Synthesis of a Network Structure Hydroxyapatite by Bovine Serum Albumin Monolayer Induction

作　　者：薛中会[1] 张兴堂[1] 陈艳辉[1] 戴树玺[1] 李蕴才[1] 黄亚彬[1] 李铁津 杜祖亮[1] 

机构地区：[1]河南大学特种功能材料省重点实验室,开封475001 [2]吉林大学化学系光化学实验室,长春130023

出　　处：《无机化学学报》2004年第12期1426-1428,共3页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金资助项目(No.90306010;20371015);"973"前期专项资助课题(No.2002CCC02700)

摘　　要：LB (Langmuir-Blodgett) technology was used to prepare the BSA monolayers m ore closely related to the half-layer biological membrane structure. The influen ce of bovine serum albumin (BSA) was studined on the polymorph, morphology and g rowth orientation of hydroxyapatite in the process of the biomineralization. XRD and SEM were respectively used to analysis the polymorph and morphology of the crystal induced by BSA monolayers. The results of XRD show that the HAP grows on ly along the (112) face, indicating a well oriented face in HAP. In addition, SE M shows that the morphologies of the HAP is of a network structure. In conclusio n, when the BSA form monolayers, it can be used as a template to induce the HAP to crystallize. Accordingly, the monolayers of the protein can be used to induce the inorganic materials to grow with a complex morphology and a well oriented f ace by biomimetic approach.LB (Langmuir-Blodgett) technology was used to prepare the BSA monolayers more closely related to the half-layer biological membrane structure. The influence of bovine serum albumin (BSA) was studined on the polymorph, morphology and growth orientation of hydroxyapatite in the process of the biomineralization. XRD and SEM were respectively used to analysis the polymorph and morphology of the crystal induced by BSA monolayers. The results of XRD show that the HAP grows only along the (112) face, indicating a well oriented face in HAP. In addition, SEM shows that the morphologies of the HAP is of a network structure. In conclusion, when the BSA form monolayers, it can be used as a template to induce the HAP to crystallize. Accordingly, the monolayers of the protein can be used to induce the inorganic materials to grow with a complex morphology and a well oriented face by biomimetic approach.

关 键 词：牛血清蛋白 单层膜 网状结构 羟基磷灰石 生物矿化 取向生长 陶瓷薄膜 仿生合成 生物材料 

分 类 号：TB383[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]