放射性脑损伤的磁共振氢质子波谱特点(英文)  

Characteristics of ~1H-magnetic resonance spectroscopy of the radiation injury of brain

作　　者：罗柏宁[1] 郭媛[1] 张波[1] 梁康福[1] 孙庚喜[1] 

机构地区：[1]中山大学附属第一医院放射科,广东省广州市510080

出　　处：《中国临床康复》2004年第34期7803-7805,共3页Chinese Journal of Clinical Rehabilitation

基　　金：广东省科委自然科学基金(980071)~~

摘　　要：背景:放射性脑损伤是鼻咽癌放射性治疗(简称放疗)后的严重并发症,其早期诊断目前仍有一定困难,而磁共振波谱(magneticresonancespec-troscopy,MRS)能无创性地检测脑组织细胞代谢,是对放疗后脑损伤检测较理想的手段和方法。目的:探讨磁共振波谱对放射性脑损伤的表达。设计:以诊断为依据,非随机化同期对照研究。单位:中山大学附属第一医院放射科。对象:对1998-10/2002-12临床证实因鼻咽癌行颈部鼻咽部放疗后,在中山大学附属第一医院放射科追踪治疗并行MRI和MRS检测76例(病变组)。同期选择无鼻咽癌及放疗史的健康者25例用同样的方法进行检测作对照组。干预:用1.5TMR成像系统和氢波谱采集分析软件,对两组对象行常规MRI和MRS检测。波谱检测序列:单容积波谱定位序列,激励回波探测法,扫描参数TR2000ms,TE135ms,FOV180mm×180mm,感兴趣区取20mm×20mm×20mm(8cm3),采集时间6.5min。MRS波峰形态分析,按NAA,Cr,Cho波峰的高低排列不同组合,分Ⅰ型、Ⅱ型和Ⅲ型。波峰积分值分析,取病变中央区、边沿区和正常区的3个主要波峰:NAA峰,Cr峰,Cho峰,用随机的软件包测各自的积分值并分别计算NAA/Cr,NAA/(Cr+Cho)和Cho/Cr的积分值比。主要观察指标:①病变组和对照组不同部位波型。BACKGROUND:The radiation injury of brain is the severe complication of nasopharyngeal carcinoma(NPC) after radiation therapy. But it is difficulty to diagnose in the early stage.Magnetic resonance spectroscopy(MRS) is sensitive to the cellular metabolism in the tissue of brain,so it is the best method to detect the radiation injury of brain after radiation therapy. OBJECTIVE:To investigate the expression of MRS for the radiation injury of brain. DESIGN:A non randomized homochronous and controlled trial based on the diagnosis. SETTING:Department of Radiation,the First Affiliated Hospital of Sun Yat sen University. PARTICIPANTS:As lesion group,76 patients,who was selected from the Department of Radiation of the First Affiliated Hospital of Sun Yat sen University,were given follow up therapy and assayed with MRI and MRS from October 1998 to April 2002.All patients were treated with the radiation therapy of nuchae and nasopharynx after the clinical diagnosis of NPC.As control group,25 health persons with neither NPC nor the history of radiotherapy were selected and assayed with the same method. INTERVENTIONS:The software of 1.5T MR imaging system and hydrogen(H) spectroscopy were used to assay normal MRI and MRS.The sequences of spectrum were as follows:single volume spectroscopy(SVS),stimulated echo acquisition method(STEAM). And MRI scan parameters consisted of repetition time(TR)=2 000 ms,echo time(TE)=135 ms,field of view(FOV)=180 mm×180 mm,volume of interest(VOI)=20 mm×20 mm×20 mm (8 cm3),and acquisition time=6.5 minutes.The analysis of MRS peak form:There were 3 types on the basis of different peak values of NAA,Cr and Cho,including type Ⅰ,type Ⅱand type Ⅲ.The analysis of integral peaks values:Three main integral peak values (NAA,Cr,Cho) were detected and the ratios of NAA/Cr,NAA/(Cr+Cho) and Cho/Cr were calculated by randomization software in central, lateral and normal area of lesion. MAIN OUTCOME MEASURES:①Forms of different sites in lesion group and control group.②Peak values and t

关 键 词：放射性脑损伤 磁共振波谱 氢质子 鼻咽癌 放射治疗 

分 类 号：R818.81[医药卫生—放射医学]