口服布洛芬与对乙酰氨基酚治疗小儿高热各60例的疗效比较  

Comparative efficacy of oral ibuprofen and paracetamol in treating sick children with high fever 60 each

作　　者：蔡幸生[1] 林锡平[1] 王萍 徐海玲[1] 

机构地区：[1]揭阳市人民医院儿科,广东揭阳522000

出　　处：《中国新药与临床杂志》2004年第12期876-878,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :比较口服布洛芬与对乙酰氨基酚治疗小儿高热的疗效。方法 :将 12 0例各种原因引起的高热 (腋下温度≥ 39°C)病儿按入院顺序分为布洛芬组和对乙酰氨基酚组 ,每组各 6 0例。布洛芬组男性 32例 ,女性 2 8例 ,年龄 (3.6±s 2 .5 )a ,予口服布洛芬混悬液或混悬滴剂 8mg·kg- 1。对乙酰氨基酚组男性 35例 ,女性 2 5例 ,年龄 (3.7± 2 .6 )a ,予口服对乙酰氨基酚混悬液或混悬滴剂 15mg·kg- 1。服药后 0 .5 ,1,1.5 ,2 ,4 ,6 ,8h各测腋下体温 1次 ,比较 2组每次体温及退热例数。结果 :服药 1h后 ,布洛芬组体温明显低于对乙酰氨基酚组 ,分别为(38.0± 0 .6 )°C ,(38.5± 0 .5 )°C ,P <0 .0 1。服药2h后 ,布洛芬组退热病例多于对乙酰氨基酚组。布洛芬组和对乙酰氨基酚组不良反应发生率分别为12 %和 15 % (P >0 .0 5 )。结论AIM: To compare the effect of oral ibuprofen and paracetamol in treating children with high fever. METHODS: One hundred and twenty patients suffering from different diseases with high fever(axillary temperature≥39 (°C))were divided into two groups according to sequence of admission. Sixty patients (M 32, F 28; age(3.6±s 2.5)a) were in ibuprofen group and 60 patients (M 35, F 25; age((3.7)±2.6)a) were in paracetamol group.Ibuprofen suspension or inbuprofen suspension drops 8 mg·kg^(-1) were orally administrated in ibuprofen group.Paracetamol suspension or paracetamol suspension drops 15 mg·kg^(-1) were orally administrated in paracetamol group. The (patients') temperature were measured (0.5), 1, 1.5, 2, 4, 6, 8 h after drugs administration.The patients' average temperature and the number of fever-free patients were compared between ibuprofen group and paracetamol group in each time. RESULTS: One hour after drugs administration, the temperature of patients were (38.0±0.6) (°C) and (38.5±0.5) (°C) in ibuprofen group and paracetamol group, respectively (P<0.01). The number of fever-free patients(≤37 (°C)) in ibuprofen group was more than that in paracetamol group 2 h after drugs administration. The adverse reaction rate was 12 % and (15 %) in ibuprofen and paracetamol group, respectively (P>(0.05).) CONCLUSION: The antipyretic effect of ibuprofen in treating the children with high fever is superior to that of paracetamol.

关 键 词：布洛芬 发热 醋氨酚 乙酰氨基酚 治疗 

分 类 号：R971.1[医药卫生—药品] R927.9[医药卫生—药学]