^(99m)Tc-MIBI心肌断层定量显像在冠心病的应用  

APPLICATION OF ^(99m)Tc-MIBI MYOCARDIAL TOMOGRAPHY AND QUANTITATIVE ANALYSIS WITH POLAR BULL'S EYE PLOT IN PATIENTS WITH CORONARY HEART DISEASE

作　　者：梁宏[1] 石锐[1] 林增桃[1] 曾世荃[1] 李春亿[1] 陈棠华[1] 赵秀珍[1] 吴克林[1] 李伟明[1] 刘革乐[2] 郑振声[2] 欧阳荣[2] 杨绪泉[2] 孙冰[2] 梁焕桢[2] 

机构地区：[1]中山医科大学附属第一医院核医学科 [2]中山医科大学附属第一医院心血管内科

出　　处：《中山大学学报（医学科学版）》1993年第1期39-43,共5页Journal of Sun Yat-Sen University:Medical Sciences

摘　　要：10例正常人及101 例冠心病(CHD)患者进行了。~99mTC-MIBl心肌断层显像及极坐标靶心图定量分析,定量参数有缺损范围分数与严重积分。定性与定量分析检出病变冠脉的灵敏度分别为86.7％和93.3％,特异性均为93·3％,虽两者之间差异无显著意义(P>0·05),但靶心图显示具有易于分析、客观和定量的优点。80个受检者同时做了核素心功能显像,结果表明靶心图定量分析计算的心肌梗塞范围与严重程度同左心功能呈明显负相关,并能通过多元回归公式预测,对31例CHD患者进行了疗效评价,体外反搏治疗后其缺血范围与严重程度均明显改善。In this study, 10 normal subjects and 101 patients with CHD undergone 99mTc-MIBI myocardical SPECT were presented and analysed with polar Bull,s eye plot (PBP). The extent and severe scores in infarcted area were calculated automatically by computer. The sensitivity of tomography and PBP for detecting stenosed coronary arteries was 0.867 and 0.933 respectively ( P>0.05) .The specificity of both techniques was the same (0.933). However, as compared with general inspection of the images, obviously the advantage of PBP was objective, quantitative and easy to analyse. In comparson with the findings of simultaneously performed 99mTc-RBC multi-gated ventriculography, the extent and severe scores well correlated with the left ventricular function. The study was also designed to assess the external counterpulsation (ECP) and drugs therapy for 31 patients with CAD. The amount of the left ventricular hypoperfused myocardium significantly reduced after ECP adding drug therapy.

关 键 词：MIBI 冠心病 严重程度 CHD 患者 心肌 体外反搏治疗 范围 客观 改善 

分 类 号：R541.4[医药卫生—心血管疾病] R542[医药卫生—内科学]