布舍瑞林(Buserelin)在体外受精中应用及对排卵前卵泡液类固醇的影响  

THE AVAILABILITY OF BUSERELIN ON IN VITRO FERTILIZATION PROGRAMME AND ITS EFFECTS OF STEROID CONCENTRATIONS IN PREOVULATORY FOLLICULAR FLUID

作　　者：庄广伦[1] 顾正田[1] 周灿权[1] 

机构地区：[1]中山医科大学附属第一医院妇产科

出　　处：《中山大学学报（医学科学版）》1993年第2期124-128,共5页Journal of Sun Yat-Sen University:Medical Sciences

摘　　要：从外周血及卵泡液中的激素水平评估两种不同超排卵方案在体外受精与胚胎移植中的作用。采用枸橼酸氯(?)酚胺(枸檬酸克罗米芬,clomiPhen citrate,CC)、人更年期促性腺激素(HMG)、人绒毛膜促性腺激素(hCG)进行联合(CHh)超排卵13例,采用促性腺激素释放激素激动剂(GnRH-a)的制剂布舍瑞林(buserelin)结合HMG/hCG(BHh)者11例。过早LH峰发生率CHh组为3/13,BHh组为0/11。BHh组妊娠4例,CHh组1例。卵泡液中黄体酮(P)及雌二醇(E_2)浓度,P/E_2 比值BHh组均低于CHh组。P/E_2比值在一定范围内对卵子受精有利。The effects of two protocols of controlled ovarian hyperstimulation were assessed with the changes of hormones of peripheral blood and follicular fluid in an in vitro fertilization and embryo transfer. Thirteen women used CC-HMG-hCG(CHh protocol),the remaining 11 women were given one of agents of gonadotropin-releasing hormone agonist, Bu-serelin with HMG-hCG (BHh protocol). Incidence of premature LH surge was 3/13 in CHh, while 0/11 in BHh. The rates of oocyte retrieval and fertilization and cleveage were higher in BHh than in CHh (P<0.005). There were four pregnancies in BHh, only one in CHh. The means follicular fluid (FF) concentrations of estradiol (E2) and progesterone (P) were significantly lower in BHh than in CHh (P<0.05) as were FF P/E2 ratio (P<0.05). FF P/E2 ratio had the benifit on oocyte fertilization in a limiting ranges.

关 键 词：CH 卵泡液 排卵前 体外受精 类固醇 HMG 比值 卵子 激素水平 人绒毛膜促性腺激素 

分 类 号：R711[医药卫生—妇产科学] R321[医药卫生—临床医学]