卡那霉素对豚鼠耳蜗碳酸酐酶活性的影响  

The effect of kanamycin (KM)on carbonic anhydrase(CAH)of the guinea pig’s cochlea

作　　者：郑蓓[1] 刘顺利[1] 白仙娥[1] 吴润身[1] 王锦玲[1] 

机构地区：[1]山西医学院第二附属医院耳鼻咽喉科,第四军医大学西京医院耳鼻咽喉科

出　　处：《耳鼻咽喉（头颈外科）》1994年第1期9-12,共4页Chinese Arch Otolaryngology-Head Neck Surg

摘　　要：本实验对豚鼠在卡那霉素（ＫＭ）致聋后和对照组进行了碳酸酐酶（ＣＡＨ）组织化学活性研究，结合图象分析技术和听觉脑干反应（ＡＢＲ）测试，观察豚鼠用ＫＭ后听力发生变化时耳蜗ＣＡＨ的变化。探讨了耳蜗内、外毛细胞区及血管纹ＣＡＨ的变化及其与听功能的关系。结果指示，ＫＭ所致听力损伤与耳蜗ＣＡＨ的变化有关。Abstract Histochemical assessment of CAH activities in KM treated guinea pig cocmea were studied with image analyzing technique and auditory brain stem response(ABR).The relationship of ABR threshold and the changes of CAH in the inner and outer hair cell regoins and stria vascuiaris were discussed.The resiuts suggested that the auditory damage of guinea pigs induced by KM was obviously correlated to changs of CAH in the cochlea.

关 键 词：CAH 耳蜗 豚鼠 碳酸酐酶 听觉脑干反应 对照组 听功能 酶活性 卡那霉素 组织化学 

分 类 号：R764[医药卫生—耳鼻咽喉科] R394[医药卫生—临床医学]