桂枝汤对体温双向调节作用机理探讨──对下丘脑5－羟色胺的影响  

Mechanism of Guizhi Tang (桂枝汤) on Dual--DirectionalThermoregulation-Effect on 5-HT in Hypothalamus of Rats

作　　者：富杭育[1] 周爱香 郭淑英[1] 田甲丽[1] 

机构地区：[1]中国中医研究院中药研究所

出　　处：《中药药理与临床》1995年第2期1-4,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：脑室注射５－ＨＴ，一小时内能诱致大鼠发热。测定发热大鼠和体温低下大鼠下丘脑组织的５－ＨＴ及其代谢产物５一羟吲哚醋酸（５－ＨＩＡＡ）的含量，发现在发热动物中５－ＨＴ含量升高，５－ＨＩＡＡ含量下降；在低体温大鼠，５－ＨＴ和５－ＨＩＡＡ含量均较正常降低。桂枝汤口饲给药，既能抑制５－ＨＴ脑室注射引起的发热反应；在解热和提高低体温动物肛温的同时，能使发热大鼠下丘脑中５－ＨＴ含量显著降低，５－ＨＩＡＡ含量升高；使低体温大鼠下丘脑的５－ＨＴ含量上升、５－ＨＩＡＡ含量下降。实验结果提示，桂枝汤对体温的双向调节，部分通过影响体温中枢神经递质５－ＨＴ实现的。-hydroxytryptamine (5-HT) and its metabolite 5-hydroxy indole-acetic acid (5-HIAA) were determined in thehypothalamus of febrile or hypothermic rats.The content of 5-HIAA was increased and o-HIAA was decreased infebrile. but both 5-HT and 5-HIAA were lowered in hypothermic rats in comparison with the level of normal animal.The fall in body temperature was associated with a large decrease in 5-HT and an increase in 5-HIAA in hypothalamuswhen Guizhi Tang was given orally to febrile rats.The rise in body temperature was lso associated with an increase in5-AT and a decrease in o-HIAA in hypthalamus of hypothermic rats by Guizhi Tang. The Tang could block the fevercaused by intra-cerebroventricular microinjection of 5-HT. The evidence sugyested that Guizhi Tang causes dualdlirectional thermoregulation through its partial action on the metabolism of 5-HT,a neurotransmitter in preoptic amierior hypothalamus.

关 键 词：桂枝汤 体温 双向调节作用 下丘脑 5-羟色胺 发热 实验 

分 类 号：R255.1[医药卫生—中医内科学] R285.5[医药卫生—中医学]