胀果甘草提取物G9314抗突变、抑制体内亚硝胺生成和对抗促癌剂诱发的脂质过氧化作用  

Antimutagenic, antioxidant and preventive effects OfG9314 on acute liver toxicity induced by aminopyrin and sodium nitrite

作　　者：傅乃武[1] 刘朝阳[1] 全兰平[1] 张如意[1] 

机构地区：[1]中国医学科学院肿瘤研究所,北京医科大学药学院植化室

出　　处：《中药药理与临床》1995年第2期20-23,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：Ｇ９３１４是从胀果甘草中提取的含有３个三萜类化合物的复合物。它有效对抗环磷酰胺诱发的小鼠骨髓微核细胞增加，明显减轻氨基比林和亚硝酸钠对小鼠肝脏的急性毒性。体外试验它显著抑制巴豆油诱发的Ｂａｌｂ／ｃ新生幼鼠皮肤表皮细胞和Ｗｉｓｔａｒ大鼠中性粒细胞的化学发光（ＣＬ）。明显对抗巴豆油对Ｂａｌｂ／ｃ小鼠肝线粒体的脂质过氧化作用，使丙二醛量明显减少。对ＣＣｌ４诱发的Ｂａｌｂ／ｃ小鼠肝微粒体ＣＬ有明显抑制。小鼠口服Ｇ３１４肝脏超氧化物歧化酶量明，显增加。AbstractG9314 was a complex extracted from Glycyrrhizae inflate Bat (III) and consisted of 3 triterpenoid compounds.It effectively prevented the increase of mouse bone marrow micronuclei induced by cytoxan. and prevented the acuteliver toxicity of mouce inducde by aminopyrin and sodium nitrite. In vitro test. it could inhibit the chemiluminescence(CL) of new born Balb/c mouse epidermis.the polymorphonuclear leukocyte (PMN) of Wistar rats and the liver mitochondtia of Balb/c mouse induced by croton oil.The CL of mouse liver microsome induced by CCl4 was also markedlyinhibited. SOD activity of mouse liver was elevated when G9314 was given per orally.

关 键 词：胀果甘草提取物 G9314 亚硝胺 脂质过氧化 化学发光 中性粒细胞 超氧化物歧化酶 试验 

分 类 号：R285.5[医药卫生—中药学]