沙参麦冬汤对大鼠胃粘膜保护作用的机理研究  

Mechanism of Protective Effects of Sha Shen MatDong Tang on Gastric Mucosa in Rat

作　　者：曹西华[1] 侯家玉[1] 

机构地区：[1]北京中医药大学药理教研室

出　　处：《中药药理与临床》1995年第5期1-3,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金

摘　　要：本实验以胃粘膜血流量、脂质过氧化物、还原型谷膛甘肽、谷膛甘肽过氧化酶及ＳＯＤ为指标探讨了沙参麦冬汤对胃粘膜保护作用的机理。结果显示，沙参麦冬汤（１０ｇ／ｋｇ，２０ｇ／ｋｇ）胃内给药能显著抑制酸化乙醇所引起的大鼠胃体、窦部粘膜血流量的下降；预先给大鼠灌胃则能显著抑制乙醇引起的胃粘膜过氧化脂质含量升高，增加还原型谷腕甘肽含量。he experiment were performed to inverstigate the protective effects of 'SSMDT')on gastric mucosa. We observedthe effects of decovtion of 'SSMDT' on gastric mucosal blood flow and on reduced glutathione, lipid peroxidation andon SOD.The results show that 'SSMDT' given intragastrically in doses of 109/kg or 209/kg 'significantly inhibitedthe reduction of mucosal blood flow induced by 50% ethanol-0.15M HCI in gastric antrum and corpus. 'SSMDT'given orally in doses of 10g/kg or 20g/kg markedly inhibited the increase of gastric mucusal LPO induced by 50%ethanol-0.15M HCI and increased the level of reduced glutathine. But the enzyme activity of SOD and the glutationePeroxidase were not affected by 'SSMDT'.

关 键 词：沙参麦冬汤 大鼠 胃粘膜保护 药理学 中药 实验 脂质过氧化 

分 类 号：R259.73[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]