番泻甙对大鼠心肌收缩性能的影响  

Effects of sennosides on myocardial COniractility in rats

作　　者：林秀珍[1] 郭世锋 刘艳霞[1] 马德禄[1] 

机构地区：[1]天津医科大学药理教研究室

出　　处：《中药药理与临床》1995年第5期28-30,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：麻醉大鼠实验结果表明，番泻甙（７．４ｕｍｏｌ·Ｌ－１·Ｋｇ－１）ｉｖ具有正性肌力作用。给药后ＨＲ加快，ＳＰ、ＭＡＰ和ＬＶＰＳ较对照组明显升高（Ｐ＜０．０５）。ｔ－ｄｐ／ｄｔｍａｘ缩短，与ｄｐ／ｄｔｍａｘ、ＶｃＥ－ＣＰＩＰ和Ｖｍａｘ增加相一致。反映心肌消耗能量与耗氧的ＴＴＩ．ＨＲ在给药后５ｍｉｎ时较对照组增加５６％，１０ｍｉ。时增加８０％，说明番泻甙升压增加左室作功，从而使心肌耗氧耗能增加。he results were shown in anesthetized rats SEN (sennosides) possesses a positive inotropic effects. after vein administration.The HR was increased,theSP,MAP and LVPS were obviousty elevated compared With that of the control groups (P<0.01 ). The shortening of t-dp/dtmax was consistent with the increases dp/dtmax, Vce-CPIP and Vmax TheTTI. HR (minute tension time index), as a standard for both.myocardial energy and oxysen consumption, was increase of 56% and 80% respectively after administration of SEN in 5min and 10min compared with control groups.This paper showed the SEN increase left ventricle working load,and consequently increase the myocardial consumptionof energy.

关 键 词：番泻甙 大鼠 心肌收缩性能 实验 药理学 心功能 血液动力学 

分 类 号：R285.5[医药卫生—中药学]