IUGR孕妇血E_3、HPL、TXB_2、6-keto-PGF_(1α)水平的测定及川芎嗪治疗后改变  

BLOOD LEVELS AND THEIR RESPONSES TO TETRAMETHYLPYRAZINE THERAPY OF E_(3),HPL,TXB_(2),6-KETO-PGF_(1α) IN PREGNANT WOMEN WITH IUGR

作　　者：赵明[1] 吴华[1] 胡健[1] 许建平[2] 

机构地区：[1]同济医科大学附属同济医院核医学科 [2]同济医科大学附属同济医院妇产科

出　　处：《放射免疫学杂志》1995年第1期6-8,共3页Journal of Radioimmanology

摘　　要：检测了58例IUGR孕妇血不同孕周血E_3、HPL、TXB_2、6-keto—PGF_(1α)水平,其中47经川芎嗪(TMPZ)治疗后观察其变化,并以89例正常孕妇结果作对照。结果表明IUGR孕妇自30周后E_3、HPL显著低于正常(p<0.001)。TXB_2/6-keto-PGF_(1α)失衡,主要表现为6-keto-PGF_(1α)随孕周增加明显减少(p<0.001)。并对IUGR病理生理变化进行初步探讨。经TMPZ治疗组E_3、HPL接近或超过正常水平,TXB_2/6-keto-PGF_(1α)失衡得到明显改善(p<0.05),表明TMPZ具有调节TXA_2/PGI_2平衡,改善胎盘功能等作用。Blood levels and their responses to tetramethylpyrazine (TMPZ) therapy of E3, HPL, TXB2, 6-keto-PGF1α were determined with radioimmunoassay method in 89 women with normal pregnancy and 58 pregnant women with IUGR,47 of them received tetramethylpyrazine (TMPZ) treatment. The results showed that after 30 weeks of gestation, the women with IUGR had significant lower levels of E3 and HPL(p<0.001) than those in normal pregnancies. Also, decreased levels of 6-keto-PGFla and increased ratios of TXB2/6-keto-PGFla were demonstrated in IUGR group during different gestation periods. In the cases received treatment with TMPZ, normal or higher E3 or, HPL levels were achieved and TXB2/6-keto-PGF1α ratios were reversed toward normal (p<0.05), Our results suggested that TMPZ might regulate the balance of TXA2/PGI2, thus improve placental function. The pathophysiological changes of IUGR were also discussed.

关 键 词：TXB2 HPL IUGR 6-KETO-PGF1Α 治疗后 孕妇血 川芎嗪 水平 孕周 变化 

分 类 号：R714[医药卫生—妇产科学] R285.5[医药卫生—临床医学]