核苷酸和P2Y受体与伤害性感受研究进展(英文)  

Nucleotides, P2Y receptors and nociception: update review

作　　者：谢玉丰[1] 唐敬师[1] 

机构地区：[1]西安交通大学医学院生理学教研室,陕西西安710061

出　　处：《中国神经科学杂志》2004年第6期466-470,共5页

基　　金：国家自然科学基金 (3 0 2 70 45 3 )资助项目

摘　　要：P2Y受体是代谢性G 蛋白偶联受体 ,在哺乳动物已发现 8种P2Y受体 ,它们多表达在外周神经末梢、脊髓背根神经节神经元和脊髓神经元等部位。其配体为ATP、ADP、UTP和UDP等。P2Y受体可从外周和脊髓等水平对伤害性感受进行调制。P2Y受体调制伤害性感受的机制可能和增加细胞内钙离子浓度有关 ,也可能和VR1有关。P2Y receptors are metabotropic G-protein coupled receptors. At least 8 functional mammalian P2Y receptors have been cloned, characterized and formally recognized as members of the P2 receptors family. The P2Y receptors are expressed mainly in peripheral nerve terminal, DRG and spinal cord neurons. The ligands of P2Y receptors are ATP, ADP, UTP and UDP. P2Y receptors may modulate the nociception processes at peripheral and spinal cord levels. Involvement of P2Y receptor in pain modulation may be related to the capsaicin receptor (VR1) and the enhancement of intracellular calcium concentration.

关 键 词：核苷酸 ATP UTP P2Y受体 伤害性感受 

分 类 号：Q426[生物学—神经生物学]