硝酸羟胺对小鼠胚胎毒性的初步研究  

Embryotoxicity and Teratogenicity of Han in Mice

作　　者：贾庆军[1] 周燕虹[1] 刘晋祎[1] 杨录军[1] 刘胜学[1] 曹佳[1] 

机构地区：[1]第三军医大学军事预防医学院卫生毒理教研室,重庆400038

出　　处：《癌变．畸变．突变》2004年第6期368-371,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：军队指令性课题(No.180.3160-O1L015);国家杰出青年基金资助项目(No.30125037);军队杰出青年基金资助项目(No.01J014)

摘　　要：背景与目的:探讨硝酸羟胺对小鼠的胚胎毒性、致畸作用和致畸特性。材料与方法:采用小鼠致畸试验,测量孕鼠体重、胎鼠体重、胎盘重量,统计胎鼠死亡率和吸收率,观察内、外部畸形,并对胎鼠的胸骨、指骨、骶尾椎等骨骼的骨化点的骨化程度进行计数;运用方差分析、X2检验等方法对所得数据进行统计分析。结果:低剂量组(7 mg/kg),中剂量组(20mg/kg)高剂量组(60 mg/kg)的孕鼠体重、胎鼠体重、胎盘重量、胎鼠死亡率和吸收率、胎鼠畸形率、骨骼骨化数,与阴性对照组差异无显著性,而阳性对照组与阴性对照差异有显著性。 结论:在7-60 mg/kg剂量范围内硝酸羟胺对小鼠没有胚胎毒性和致畸作用。BACKGROUND & AIM: To study the embryotoxicity, the teratogenic effect of Hydroxylammonium Nitrate (HAN) and its teratogenic characteristics. MATERIAL AND METHODS: The body weight,the death rate of fetuses and the rate of absorbed embryos were counted. The External appearances and internal organ and the skeleton of the mouse embyos were observed . RESULTS:After the mice were given different doses of HAN,their weight, the number of living embryo, the number of absorbed embryo and the number of dead embryo did not change obviously. The weight of the embryo did not changed apparently. The abnormality in statistics was not found in the skeleton of the mouseembryos, the exterior and the internal organs. CONCLUSION: HAN has no malformed effect on the mouse embryos.

关 键 词：硝酸羟胺 致畸性 胚胎毒性 

分 类 号：R994.6[医药卫生—毒理学]