声学造影评价兔腹主动脉粥样硬化的初步研究  

Enhanced ultrasonography of atherosclerosis of abdominal aorta in rabbit model: a preliminary study

作　　者：李馨[1] 高云华[2] 谭开彬[2] 司良毅[1] 刘平[2] 

机构地区：[1]第三军医大学西南医院老年病科,重庆400038 [2]第三军医大学新桥医院超声科

出　　处：《中国医学影像技术》2004年第11期1680-1682,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金项目资助 (30 2 0 0 2 65)

摘　　要：目的　探讨超声造影在动脉粥样硬化中的诊断价值。方法　新西兰大白兔 5只 ,高脂饮食喂养 12周建立动脉粥样硬化模型。模型建立前后应用自制的脂膜氟碳声学造影剂“脂氟显”行腹主动脉超声造影。造影前后分别采用二维成像、视觉评分和视频密度法监测兔腹主动脉内膜、粥样斑超声成像特征并作定量分析。结果　造影后血管内膜、粥样斑回声明显增强 ,视频密度较造影前明显增加。结论　造影剂可提高血管内膜分辨率及粥样斑检出率 。Objective To discuss the value of enhanced ultrasonography in monitoring atherosclerosis. Methods Five New Zealand rabbits were fed with cholesterol diet for 12 weeks in order to create the animal model of atherosclerosis. The images for abdominal aorta were obtained continuously after intravenous injection of self-made microbubbles (ZhiFuXian). The videointensity of intima and plaque were compared with those without contrast agent. Results Significant increases for intima and plaque videointensity were observed after microbubbles injection. Conclusion Enhanced ultrasonography is very effective for sonography improvement in detecting early atherosclerosis. [

关 键 词：声学造影 动脉粥样硬化 腹主动脉 

分 类 号：R543.5[医药卫生—心血管疾病] R445.1[医药卫生—内科学]