消脂宁片质量控制的研究  

Quality criteria of xiaozhining tablet

作　　者：滕英博[1] 张秋红[1] 李黎[1] 夏曙辉[1] 

机构地区：[1]南京军区南京总医院制剂科,江苏南京210002

出　　处：《医学研究生学报》2004年第12期1065-1067,1071,共4页Journal of Medical Postgraduates

摘　　要：目的 :建立消脂宁 (xiaozhining)片质量控制方法。　方法 :用薄层层析法 (TLC)鉴定消脂宁片中的黄芩、丹参、大黄、益母草成分。用高效液相色谱法 (HPLC)测定消脂宁片中大黄素含量。　结果 :TLC法对处方中四种主要成分鉴定结果满意 ;HPLC法测定大黄素含量 ,回归方程为A =2 .4 3× 10 7C +6 .0 6× 10 4(r =0 .9997) ,在 0 .0 5～ 0 .5mg/ml范围内线性关系良好 ,加样回收率为 96 .70 % ,相对标准差 (RSD) =1.0 6 % ,3批供试品中大黄素含量平均值为 0 .0 2 14mg/片 ,RSD =1.5 4 %。方法稳定可靠。　结论Objective: To establish the quality criteria for xiaozhining tablet. Methods: TLC method was applicated to determine and differentiate the Scutellaria , the Radix salviae miltiorrhizae, the Rheum, the Leonurus of the tablet. HPLC method was used for detecting the content of emodin in xiaozhining Tablet. Results: Four main components of the tablet was determined well. The regression equation by HPLC was A=2.43×10 7C+6.06×10 4(r=0.999 7). Curcumin had good linear relation within the range of 0.5～0.05 mg/ml. The average recovery rate was 96.70%(RSD=1.06%). The average value of emodin was 0.021 4 mg. Conclusion: The method of determination is reliable. It can be used as the basis for the quality control of xiaozhining Tablet.

关 键 词：消脂宁片 薄层层析鉴定 大黄素 HPLC法 含量测定 

分 类 号：R284.2[医药卫生—中药学]