新诊断1型糖尿病患者血清瘦素质量浓度及短期胰岛素治疗对其影响  

Level of serum leptin in newly diagnosed type 1 diabetic patients and the effect of short-term insulin therapy on it

作　　者：丛丽[1] 李强[1] 张巾超[1] 孙予倩[1] 刘凤晨[1] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌代谢病科,150086

出　　处：《中国实用内科杂志》2004年第12期734-736,共3页Chinese Journal of Practical Internal Medicine

基　　金：国家自然科学基金 (编号 :3 9970 3 44)

摘　　要：目的　观察新诊断 1型糖尿病患者血清瘦素质量浓度变化及胰岛素治疗对瘦素质量浓度的影响 ,进而探讨胰岛素和瘦素间的相互作用。方法　 1999- 0 7～ 2 0 0 0 - 0 7哈尔滨医科大学附属第二医院门诊和病房 2 9例新诊断的 1型糖尿病患者和 2 0名正常对照者彻夜空腹 14h后 ,第 2天早晨 8时采血检测血糖、HbA1c、甘油三酯、胆固醇、胰岛素、C肽及瘦素 ,然后对 1型糖尿病患者行皮下胰岛素注射治疗 ,2周后检测血糖、胰岛素、C肽和瘦素。结果　新诊断的 1型糖尿病患者血清瘦素质量浓度明显低于对照者 (P <0 0 5 ) ,胰岛素治疗 2周后 ,瘦素质量浓度无明显变化 (P >0 0 5 ) ;相关分析显示 ,对照组空腹血清瘦素质量浓度与性别、体重指数 (BMI)和胰岛素浓度具有相关性 ,新诊断 1型糖尿病组血清瘦素质量浓度仅与性别、胰岛素浓度具有相关性。结论　新诊断 1型糖尿病患者在胰岛素治疗前血清瘦素质量浓度低于对照者。短期胰岛素皮下注射治疗对血清瘦素质量浓度无明显影响。Objective To observe the changes of leptin levels in newly diagnosed type 1 diabetic patients and the effect of insulin therapy on serum leptin levels,so as to investigate the relationship between insulin and leptin.Methods Twenty-nine type 1 diabetic patients were enrolled from out-patient clinic and ward of our hospital.Twenty healthy people in our hospital were selected as normal controls.All blood samples were obtained after an overnight fasting for 14 hours.Fasting serum levels of glucose,hemoglobinA 1c(HbA 1c),triglycerides,cholesterol,insulin,C-peptide and leptin were analyzed in all subjects.The type 1 diabetic patients received insulin injection subcutaneously,and levels of glucose,insulin,C-peptide and leptin were measured 2 weeks later.Results In newly diagnosed type 1 diabetic patients,leptin levels were lower than those in normal controls (P<0.05),and after receiving insulin therapy for 2 weeks,no statistical difference was observed in serum leptin levels (P>0.05).It was found by correlation analysis that in control group,serum leptin levels were correlated with sex,BMI and serum insulin levels,while in newly diagnosed type 1 diabetic group,serum leptin levels were related to sex and serum insulin levels.Conclusion Serum leptin levels of patients with newly diagnosed type 1 diabetes are lower than those in control group.It is likely that short-term insulin injection subcutaneously can not affect serum leptin levels.

关 键 词：1型糖尿病 血清瘦素 短期胰岛素 皮下注射 含量检测 

分 类 号：R587.1[医药卫生—内分泌]