玉郎伞提取物对大鼠心肌缺血再灌注损伤的保护作用  

Protective effect of Yulangsan extractive on myocardial ischemia reperfusion injury in rats

作　　者：焦杨[1] 段小群[1] 孔晓龙[2] 蒋伟哲[2] 黄仁彬[1] 

机构地区：[1]广西医科大学药理学教研室,广西南宁530021 [2]广西医科大学第一附属医院,广西南宁530021

出　　处：《中国医院药学杂志》2004年第12期726-727,共2页Chinese Journal of Hospital Pharmacy

基　　金：广西自然科学基金项目 (编号 :桂科自 9912 0 3 8)

摘　　要：目的 :研究玉郎伞 (YLS)对心肌缺血再灌注损伤 (MIRI)的影响。方法 :以Wistar大鼠制备MIRI模型 (结扎冠状动脉 5min后再灌注 30min) ,观察YLS对心肌梗死面积及心肌组织丙二醛 (MDA)含量、超氧化物歧化酶 (SOD)活力及血清中乳酸脱氢酶 (LDH)、肌酸磷酸激酶 (CK)活性生化指标的影响。结果 :YLS明显降低心肌梗死范围、提高心肌组织中SOD活力、降低其MDA含量 ,同时降低血清中CK和LDH活力 (P <0 .0 1或P <0 .0 5 )。结论OBJECTIVE To study the effect of YLS on myocardial ischemia reperfusion injury in rats.METHODS An experimental MIRI (Coronary artery ligation for 5 min followed by reperfusion for 30 min .) in wistar rats were used for the determination of the area of myocardial ischemia,the activities of superoxide dismutase (SOD),lactate dehydrogenase (LDH) and creatine kinase (CK),and the content of MDA in myocardium or serum following the pretreatment with YLS.RESULTS YLS could significantly decrease the content of MDA and the activity of CK and markedly reduce the area of myocardial ischemia and increase the activity of SOD ( P < 0.01 or P < 0.05 ).CONCLUSION YLS has a significant protective effect on myocardial ischemia reperfusion injury in rats.

关 键 词：玉郎伞 心肌缺血再灌注损伤 心肌梗死面积 超氧化物歧化酶 乳酸脱氢酶 

分 类 号：R282[医药卫生—中药学]