肉毒碱乳清酸盐对不同因素诱导的小鼠实验性肝损伤的保护作用  

Experimental studies on the preventive and therapeutic effects of Hepadif on hepatocirrhosis

作　　者：范捷 杨育红[2] 周庆峰[2] 

机构地区：[1]葫芦岛市医院,辽宁葫芦岛121001 [2]锦州医学院药理室,辽宁锦州121001

出　　处：《中国医院药学杂志》2004年第12期754-755,共2页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :研究肉毒碱乳清酸盐 (疗尔健 )对小鼠实验性肝损伤的防治作用。方法 :单次或多次给予实验小鼠CCL4油剂 ,分别造成急性肝损伤和肝纤维化 ;给小鼠静脉注射BCG和LPS造成免疫性肝损伤。检测各组实验小鼠血清ALT、AST、ALP ,并取肝损伤小鼠肝脏做病理学检查。结果 :CCL4急性肝损伤实验中 ,疗尔健 30 0 ,10 0mg·(kg·d) -1组小鼠ALT、ALP低于对照组 ;免疫性肝损伤实验中 ,疗尔健组ALT、AST显著低于对照组 ;实验性肝损伤实验中 ,疗尔健组ALT、ALP显著低于对照组。病理检查显示 ,疗尔健组肝脏损伤及纤维化程度明显减轻。结论OBJECTIVE The preventive and therapeutic effects of Hepadif on mice experimental liver fibrosis were studied.METHODS The acute liver and fibroses damaged rat models were established by giving single or multi dose of CCL 4 orally and the liver dysimmunity models were established by giving BCG and LPS intravenously.Rats were divided into Hepadif group and control group and the serum ALT,AST and ALP of the mice were examined.The liver tissues taken from the liver fibrosis mice were committed to pathological examination.RESULTS Using the CCL 4 to damage the liver acutely,the experiment shows that the serum ALT,ALP of the Hepadif 300,100 mg·(kg·d) -1 group were lower than the control one with significant differences( P < 0.05 ).In the immune liver damaged mice,the ALT and AST of the Hepadif group were significantly lower than the control one.The ALT and ALP of the Hepadif were lower than the control one in the experimental liver damaged experiment.The severity of liver fibrosis was slight in the Hepadif group in pathological examination.CONCLUSION The preventive and therapeutic effects of Hepadif on chronic liver damage and liver fibrosis are reliable.

关 键 词：肉毒碱乳清酸盐(疗尔健) 肝损伤 肝硬化 

分 类 号：R965[医药卫生—药理学]