阿霉素性心力衰竭模型与氧化应激  

STUDY ON MODEL OF HEART FAILURE WITH ADRIAMYCINThe first affiliated hospital of Guangzhou medicine college

作　　者：杨辉[1] 吴伟康[1] 

机构地区：[1]广州医学院第一附属医院,510089

出　　处：《医学动物防制》2004年第11期655-657,共3页Journal of Medical Pest Control

基　　金：广东省中医药局课题(99559);广东省科委课题(001323)

摘　　要：本实验观察了阿霉素复制慢性心衰模型的心功能、丙二醛(MDA)、超氧化物歧化酶(SOD)的动态变化发生情况,结果表明在阿霉索引起大鼠心功能显著降低的同时MDA含量显著增加,SOD活性显著下降,提示阿霉素性心力衰竭模型有异常显著的氧化应激反应发生,提示阿霉素性心衰中心肌细胞凋亡的发生与氧化应激有密切关系。Exploring the change of heart function, malondialdehyde(MDA) and superoxide dismutase(SOD) as well as apoptosis in myocardium of model of heart failure with adriamycin. Results show that content of MDA increased, activity of SOD deceased and apoptosis in myocardium bappened while heart function deceased with adriamycin. Suggesting there were oxidative stress arid apoptosis significantly in model of heart failure. Correlation analyses suggested that apeptcsis in myocardium was related to oxidative stress in heart failure with adriamycin.

关 键 词：阿霉素性 心力衰竭模型 氧化应激 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]