高血压病患者血清脂蛋白a与肱动脉血流依赖性舒张功能的关系  

RELATIONSHIP BETWEEN HYPERURICEMIA AND FUNCTION OF FLOW-MEDIATED DILATION IN PATIENTS WITH HYPERTENSION

作　　者：张俊[1] 罗开良[2] 高兴玉[1] 吕湛[1] 罗勇[1] 陈丽[1] 刘利[1] 冯杰[1] 哈磊[1] 

机构地区：[1]川北医学院附属医院心内科 [2]重庆医科大学附属第二医院心内科

出　　处：《中国心血管病研究》2004年第12期938-940,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的　探讨高血压病患者肱动脉血流依赖性舒张功能与血清脂蛋白a(Lpa)的相关关系。 方法　选择 186例原发性高血压病患者 ,另选 31例正常人为对照组。应用B超对肱动脉进行扫查 ,在静息、反应性充血时对肱动脉内径进行检测 ,计算不同状态下的管径变化及血流介导的内皮依赖性血管扩张率 (Flow -MD % )。将所有对象按Flow -MD %大小分成 4个亚组 ,比较各组Lpa情况。 结果　随血脂蛋白a浓度增大 ,Flow -MD %逐渐减小 ,脂蛋白a与Flow -MD %呈负相关关系 ,r =- 0 .6 5 2 ,P <0 .0 1。结论　高脂蛋白a与高血压病患者血管壁的早期损害有关系。Objective To investigate the relationship between lipoprotein(a) (Lpa) and function of flow-mediated(Flow-MD) dilation in patients with hypertension. Methods 186 hypertensive patients were given an examination on blood pressure, B-mode ultrasound while 31 normal persons accompanied as control. B-mode ultrasound was applied to scan the diameter of brachial artery at rest and reactive hyperemia caused by Flow-MD%. Then they were divided into four groups according to Flow-MD, and were compared their Lp(a) each other. Results With rising of serum Lp(a) level, rate of Flow-MD decreased. There was a negative relation between Lp(a) and function of flow-mediated dilation,r=-0.652,P<0.01. Conclusion High Lp(a) may induce the early lesions of arteries.

关 键 词：高血压 脂蛋白A 肱动脉 血流依赖性舒张功能 血管壁 

分 类 号：R544.1[医药卫生—心血管疾病]