巴柳氮二钠的合成  

Synthesis of Balsalazide disodium

作　　者：柴雨柱[1] 徐军[1] 王浦海[1] 冷宗康[1] 

机构地区：[1]江苏省药物研究所,江苏南京210009

出　　处：《华西药学杂志》2004年第6期431-433,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的　合成巴柳氮二钠并改进工艺。方法　以对硝基苯甲酰氯为起始原料 ,经缩合、还原、重氮化、偶合、成盐等反应制得巴柳氮二钠。结果　所得产物经元素分析、紫外光谱、红外光谱、核磁共振谱及质谱等确证了结构。结论　合成路线可行。OBJECTIVE To synthesize balsalazide disodium and optimize the process.METHODS Balsalazide disodium was synthesized by reactions of condensation , reduction, diazotization , coupling and salification from 4-nitrobenzoyl chloride. RESULTS Chemical structure of Balsalazide disodium was confirmed by element analysis, UV ,IR , 1HNMR and ESI-MS etc. CONCLUSION This synthetic method is feasible.

关 键 词：合成路线 成盐 巴柳氮 起始原料 重氮化 苯甲酰氯 缩合 反应 质谱 紫外光谱 

分 类 号：R975.6[医药卫生—药品] TQ463.5[医药卫生—药学]