并行带瓣双静脉自体移植动物模型的建立  

Establishment of an animal model to evaluatethe parallel bi-vein graft with valves

作　　者：王波[1] 赵瑜[1] 时德[1] 刘建勇[1] 黄永火[1] 

机构地区：[1]重庆医科大学临床学院血管外科,重庆400016

出　　处：《重庆医科大学学报》2004年第6期755-758,共4页Journal of Chongqing Medical University

摘　　要：目的 :探讨并行带瓣双静脉自体移植模型的建立方法 ,为原发性下肢深静脉瓣膜关闭不全寻求新的手术方法和途径。方法 :用显微外科技术为 12只新西兰兔行并行带瓣双静脉自体移植 ,并行动态彩色多谱勒和静脉造影检查以观察其血流状态和血流动力学情况。结果 :12只兔带瓣静脉自体移植一次性成功 ,术后观察 4周 ,血栓形成 1只。其余血管无明显狭窄 ,形态满意 ,血流状态稳定 ,均为层流。结论 :通过显微技术建立兔并行带瓣双静脉自体移植模型是切实可行的。Objective:To establish the parallel bi-vein graft with valves animal model and to seek a new surgical method for patients with deep valvular incompetence.Methods:The parallel bi-vein with valves autogenic graft animal model was established in 12 rabbits by microsurgery and the hemorheology and hemodynamics were examined by real time color-duplex scanning and phlebography.Results:Among all of the 12 rabbits, autogenic graft of the parallel bi-vein with valves animal model was successfully established and was under observation for 4 weeks postoperatively.Only in 1 rabbit it was obstructed after 4 weeks.The rest remained unobstructed and were kept in favorable configuration and steady blood stream with laminar flow.Conclusion:The autogenic graft parallel bi-vein containing valves by microsurgery technique in rabbits is feasible.The opretion may be a feasible and promising method for clinical patients with chronic venous insufficiency in lower limb.

关 键 词：兔 瓣膜 静脉 自体移植 模型 

分 类 号：R654.4[医药卫生—外科学] R622.4[医药卫生—临床医学]