更年宁心胶囊对阴虚内热型更年期综合征患者FSH、LH、E_2的影响及疗效  

The effect of Gengnianningxin capsule on serum FSH、LH、E_2 and symptomsin patients with female climacteric syndrome of fever due to yin-deficiency

作　　者：曹文富[1] 张文芳[1] 何英[1] 姚蔚瑜[1] 

机构地区：[1]重庆医科大学临床学院中医科,重庆400016

出　　处：《重庆医科大学学报》2004年第6期835-837,共3页Journal of Chongqing Medical University

基　　金：国家新药研究基金项目 (9690 10 5 74)。

摘　　要：目的 :观察更年宁心胶囊对女性阴虚内热型更年期综合征患者FSH、LH、E2 和临床症状的作用。方法 :采用随机数字表法将 10 5例阴虚内热型女性更年期综合征患者按 2∶1比例随机分入治疗组 70例和对照组 35例 ,分别采用更年宁心胶囊和更年安片治疗 ,疗程 30天。观察治疗后患者FSH、LH、E2 的变化及更年期症状积分值的改善情况。结果 :治疗组治疗后血清E2 水平明显升高 ,LH明显降低 ,且优于对照组 (P <0 .0 1) ;治疗组治疗后症状积分值明显改善并优于对照组 (P <0 .0 1)。结论 :更年宁心胶囊能显著改善阴虚内热型女性更年期综合征患者的血清E2 水平和临床症状 ,临床总疗效明显优于更年安片。Objective:To observe the effect of Gengnianningxin capsule on serum follicle stimulating hormone (FSH),luteinizing hormone (LH),estradiol (E 2) and clinical symptoms in patients with female climacteric syndrome of fever due to yin-deficiency.Methods:105 cases of patients with female climacteric syndrome of fever due to yin-deficiency were randomly divided into treatment group(70 cases) and control group (35 cases).Treatment group was treated by Gengnianningxin capsule,and control group was treated by Gengnianan tablet for 30 days.Levels of serum FSH,LH and E 2 were determined,meanwhile variation of symptom scores of climacteric syndrome were observed.Results:Levels of serum E 2 in the treatment group was increased significantly and levels of serum LH decreased significantly after treatment ( P <0.01).The post-treatment total symptom scores of climacteric syndrome in the treatment group were significantly improved( P <0.01).Conclusion:Gengnianningxin capsule can ameliorate significantly the levels of E 2 and LH,and clinical symptoms in patients with female climacteric syndrome of fever due to yin-deficiency.Total clinical effect of Gengnianningxin capsule is significantly better than Gengnianan tablet.

关 键 词：更年宁心胶囊 更年期综合征 雌二醇(R) 促卵泡激素(FSH) 促黄体生成激素(LH) 

分 类 号：R711.75[医药卫生—妇产科学]