大鼠背根神经节内kv2.1 mRNA和kv4.2 mRNA的表达  

Expression of kv2.1 and kv4.2 mRNA in rat dorsal root ganglion

作　　者：王劼[1] 刘才栋[1] 沈馨亚[1] 彭裕文[1] 

机构地区：[1]复旦大学上海医学院解剖与组织胚胎学系,上海200032

出　　处：《解剖学研究》2004年第1期35-36,39,i002,共4页Anatomy Research

摘　　要：目的　了解kv2 1和kv4 2型钾离子通道在背根神经节的表达。方法　应用原位杂交方法观察背根神经节内细胞膜钾离子kv2 1和kv4 2型通道的mRNA阳性神经结构的表达。结果　腰 3～ 5背根神经节内均有kv2 1和kv4 2mRNA阳性神经元的表达 ,kv4 2mRNA阳性神经元的数量和总面积明显多于kv2 1阳性神经元。结论　kv2 1和kv4 2型钾离子通道可能参与了背根神经节对外周传入信息的传递和调制。Objective In order to understand function of kv2.1 and kv4.2 type K + ion channel in DRG. Methods kv2.1 and kv4.2 type K + ion channel was showed with ISHH on the DRG in rat. Results The expression of kv2.1 mRNA-and kv4.2 mRNA-positive neurons structure in dorsal root ganglia were viewed in L3～5 DRG. The quantity and general area of kv4.2 mRNA-positive neurons in dorsal root ganglias were showed more to kv2.1 mRNA-positive neurons structure. Conclusions Opening of kv2.1 and kv4.2 type K+ ion channel probably partake in the transmission and modulation to peripheral afference in the dorsal root ganglia.

关 键 词：背根神经节 表达 RNA 钾离子通道 阳性神经元 大鼠 原位杂交方法 细胞膜 数量 传递 

分 类 号：R33[医药卫生—人体生理学]