阻断肝脏副交感神经反射而引起胰岛素抵抗但不影响胰岛素样生长因子(IGF-1)  

INTERRUPTION OF HEPATIC PARASYMPATHETIC NERVE REFLEX CAUSES INSULIN RESISTANCE, BUT NOT IGF-1

作　　者：娜荣[1] 刘振兰[1] 乌恩[2] 

机构地区：[1]内蒙古医学院第一附属医院老年病科,内蒙古呼和浩特010050 [2]内蒙古医学院药学系无机化学教研室

出　　处：《内蒙古医学院学报》2004年第4期245-247,共3页Acta Academiae Medicinae Neimongol

摘　　要：目的 :为了检验一个新的学说 :是胰岛素而不是胰岛素样生长因子 ( IGF-1 )激活肝脏副交感神经反射。方法 :应用快速胰岛素敏感试验 ( RIST)方法 ,其 RIST的指标是 :在胰岛素 (或 IGF-1 )输入后为了维持老鼠实验期间的正常血糖水平而灌注的葡萄糖量。我们比较了反应于胰岛素 5 0 m U/ kg及 IGF-1 2 0 0μg/ kg输入实验的老鼠体内后的血糖贮存量。结果 :IGF-1 2 0 0 μg/ kg与胰岛素 5 0 m U/ kg有相似的低血糖作用。通过输入阿托品 ( 1 .0 mg/ kg)阻断肝脏副交感神经反射导致胰岛素抵抗 ,而对 IGF-1无影响。结论 :是胰岛素而不是Objective: To test a new hypothesis that insulin, but not IGF-1, triggers the hepatic parasympathetic nerve reflex. Methods: With a rapid insulin sensitivity test(RIST) and its index is the amount of glucose infused after injection of a bolus of insulin (or IGF-1) to maintain the euglycemia during the test. Glucose disposal in response to IGF-1 (200 μg/kg) was compared to dose 50 mU/kg of insulin in rats. Results: 200 μg/kg of IGF-1 had similar hypoglycemic effects to 50 mU/kg of insulin. Interruption of hepatic parasympathetic nerve reflex by atropine (1.0 mg/kg) administration resulted in insulin, but not IGF-1 resistance. Conclusion: Insulin, but not IGF-1, triggers the hepatic parasympathetic nerve reflex to release a hormone that stimulates glucose uptake in the skeletal muscle.;

关 键 词：胰岛素样生长因子 胰岛素 副交感神经反射 胰岛素敏感性 

分 类 号：R587[医药卫生—内分泌]