系统性红斑狼疮患者血清S-100蛋白检测及其临床意义  

The detection of S-100 protein and its clinical significance in patients with systemic lupus erythematosus

作　　者：陶菲克[1,2] 徐祖森[1] 

机构地区：[1]华中科技大学同济医学院同济医院皮肤科,湖北武汉430030 [2]也门共和国留学生

出　　处：《临床皮肤科杂志》2004年第12期730-731,共2页Journal of Clinical Dermatology

摘　　要：目的:通过检测系统性红斑狼疮(SLE)患者血清S-100蛋白水平,探讨S-100蛋白与SLE的关系及其临床意义。方法:用ELISA法检测无神经系统症状的SLE活动期(ASLE)患者20例,SLE稳定期(ISLE)患者6例,有神经系统症状(排除了引起脑神经损害的其他神经精神疾病)的SLE患者(NPSLE)5例及10例健康人的血清S-100蛋白。结果:ASLE、ISLE、NPSLE患者血清S-100水平均高于对照组,其中NPSLE患者血清S-100蛋白水平明显高于其他组(P<0.01)。结论:SLE患者的血清S-100蛋白水平与SLE病情有一定的关系,血清S-100蛋白水平可能是反映或预示SLE脑神经受损的一个有效指标。Objective: To investigate the relationship between serum S-100 protein and systemic lupus erythematosus (SLE). Methods: Serum levels of S-100 protein were examined in SLE patients using an enzyme-linked immunosorbent assay (ELISA). Patients were grouped as inactive SLE (ISLE) (n = 6), active SLE without unequivocal neurologic manifestation (ASLE) (n = 20), or active SLE with unequivocal neurologic or psychiatric manifestation (NPSLE) (n = 5). As control 10 healthy people were also recruited. Results: The levels of serum S-100 protein were higher in all SLE groups than that in control group (P < 0.05). Among these three SLE groups, it was significantly higher in the NPSLE group (P < 0.01). Conclusions: This result presents a significant correlation between the SLE patients and serum S-100 protein. High levels of serum S-100 protein may indicate the neuropsychiatric damage of SLE.

关 键 词：红斑狼疮 系统性 神经精神损害 蛋白 S-100 

分 类 号：R593.241[医药卫生—内科学]