Synthesis of the Active Stilbenoids by Photooxidation Reaction of trans-e-Viniferin  

作　　者：姚春所 林茂 王映红 

机构地区：[1]Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

出　　处：《Chinese Journal of Chemistry》2004年第11期1350-1355,共6页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China (No. 30070889).

摘　　要：Two new stilbenoids, cis-e-viniferin (3) and 2b,14b-dehydro-bisresveratrol (4) were synthesized by photooxida-tion reaction of trans-e-viniferin (2) prepared from trans-resveratrol (1). Pentamethoxyl trans-e-viniferin (5) and pentamethoxyl cis-e-viniferin (6) were also obtained by methylation of trans-e-viniferin (2) with (MeO)2SO2. Their structures were elucidated on the basis of spectral evidence. Compounds 3 and 4 showed potent inhibition of TNF-a at concentrations of 10-5 molL-1 with inhibitory ratios of 51.43% and 36.64%, respectively.Two new stilbenoids, cis-e-viniferin (3) and 2b,14b-dehydro-bisresveratrol (4) were synthesized by photooxida-tion reaction of trans-e-viniferin (2) prepared from trans-resveratrol (1). Pentamethoxyl trans-e-viniferin (5) and pentamethoxyl cis-e-viniferin (6) were also obtained by methylation of trans-e-viniferin (2) with (MeO)2SO2. Their structures were elucidated on the basis of spectral evidence. Compounds 3 and 4 showed potent inhibition of TNF-a at concentrations of 10-5 molL-1 with inhibitory ratios of 51.43% and 36.64%, respectively.

关 键 词：PHOTOOXIDATION cis-e-viniferin 2b 14b-dehydro-bisresveratrol STILBENOID tumor necrosis factor in-hibitory activity 

分 类 号：O621[理学—有机化学]