猫隔核注射去甲肾上腺素受体阻断剂对刺激内脏大神经诱发皮质醇浓度的影响  

EFFECTS OF INJECTION OF NORADRENERGIC BLOCKING AGENTS INTO SEPTAL NUCLEI ON PLASMA CORTISOL LEVEL BY STIMULATION OF THE GREATER SPLANCHNIC NERVE OF CATS ABSTRACT

作　　者：周予谦[1] 朱晓蔓[1] 郭建侃 胡立明[2] 周伟君[3] 

机构地区：[1]南京铁道医学院生理学教研室 [2]南京大学生物学系 [3]南京铁道医学院同位素室

出　　处：《南京铁道医学院学报》1993年第1期1-4,8,共4页Journal of Nanjing Railway Medical College

摘　　要：采用健康成年猫36只,电刺激左侧内脏大神经中枢端,引起血浆皮质醇浓度的升高效应。损毁隔核后,刺激内脏大神经,皮质醇浓度升高效应消失,说明隔核可能参与诱发皮质醇升高效应的过程。隔核内微量注射心得安,可阻断刺激内脏大神经诱发皮质醇浓度的升高效应,注射酚妥拉明则无变化。结果提示,隔核参与肾上腺皮质分泌功能的调节,其作用可能是通过去甲肾上腺素(NE)能系统中的β受体来实现的。Thirty—six healthy adult cats were used in this experiment.Stimulation of the central end of the left major splanchnic nerve induced a promotion of the plasma cortisol level.After lesions of the septal nuclei,such effect disppeared.This indicated that septal nuclei might modulate the cor- tisol level.Injection of propranolol into septal nuclei blocked the enhancement,While the same treament of phentolamine made no difference.The results suggested that septal nuclei might modulate cortisol secretion by noradrenergic β—receptor

关 键 词：隔核 内脏大神经 皮质醇 

分 类 号：R338.26[医药卫生—人体生理学]