抗癌新药FH8901对膀胱癌及其他瘤株的抗癌作用和毒性的实验研究  

EXPERIMENTAL RESEARCH OF THE ANTICANCER EFFECTS OF FH 8901 ON BLADDER CARCINOMA AND OTHER NEOPLASM LINES AND ITS TOXICITY

作　　者：武文森[1] 尹克铮[1] 范贤骏 刘玉英[2] 谭文[2] 张荣久[3] 张爱华[3] 梁淑芳[3] 

机构地区：[1]南京铁道医学院病理解剖学教研室,南京210009 [2]中国医学科学院肿瘤研究所 [3]南京药物研究所

出　　处：《南京铁道医学院学报》1993年第3期137-139,共3页Journal of Nanjing Railway Medical College

摘　　要：FH8091是我们近年研制的一种抗癌新药,实验结果表明,FH8901对 W_(256)、BST_(739)、BTT_(739)、LA_(795)、MPC—83等瘤株均有较好抑瘤作用(P<0.01),对 Hep 显效,对S_(180)无效。药物疗效与剂量呈正相关,腹腔给药优于口服给药。实验结果表明 FH8901毒性低。抗瘤谱广,疗效指数较高。We have developed a new anticancer drug——FH 8901.The experiments showed that it had an inhibitory effect on carcinoma lines of W_(256),BST_(739),BTT_(739),LA_(795)and MPC-83.It showed an effectiveness on Hep but no effect on S 180(P<0.01)。The effeciency positively correlated with the dosage of the drug.Intraperitoneal administration of the drug was superior to oral one. The results indicate a low toxicity,wide antineoplastic spectrum and high therapeutic index of FH 8901.

关 键 词：抗癌药 新药 膀胱肿瘤 药理 毒性 

分 类 号：R979.19[医药卫生—药品]