紫外分光光度法和高效液相色谱法测定利巴韦林片含量的比较  

Assay of Ribavirin Tablets by UV and HPLC

作　　者：李安荣[1] 许群芬[2] 龚亚林[1] 

机构地区：[1]重庆医科大学附属第一医院,重庆400016 [2]四川大学华西第二医院,四川成都610041

出　　处：《中国药业》2004年第12期34-35,共2页China Pharmaceuticals

摘　　要：目的:建立紫外分光光度法测定利巴韦林片的含量。方法:采用紫外分光光度法和高效液相色谱法分别测定利巴韦林片的含量。结果:紫外分光光度法平均回收率为100.9%,RSD=0.57%(n=5);高效液相色谱法平均回收率为99.9%,RSD=0.86%(n=5)。结论:紫外分光光度法简便、快速,两种方法测定结果一致(P>0.05)。Objective:To establish an UV method for determining the content of ribavirin tablets.Methods:Ribavirin tablets were determined by ultraviolet spectrophotometer(UV) and high performance liquid chromatography(HPLC).Results:The average recovery of UV and HPLC was 100.9%(RSD=0.57%,n=5),and 99.9%(RSD=0.86%,n=5),respectively.Conclusion:UV method was simple and rapid,the result of two methods are similar(P > 0.05).

关 键 词：紫外分光光度法 高效液相色谱法 利巴韦林 含量测定 

分 类 号：R927.2[医药卫生—药学] R978.7