相转移催化法合成三甲氧基甲苯  

Synthesis of 3,4,5-trimethoxy-toluene with phase transfer catalysis

作　　者：崔晓君[1] 陈志荣[2] 

机构地区：[1]中国计量学院安全工程研究所,浙江杭州310018 [2]浙江大学联合化学反应工程研究所,浙江杭州310027

出　　处：《应用化工》2004年第6期65-66,共2页Applied Chemical Industry

摘　　要：采用聚乙二醇为相转移催化剂,对3,4,5 三甲氧基甲苯的合成工艺进行了优化,优化的工艺条件为:反应温度90℃,反应时间为2h,m(2,6 二甲氧基 4 甲基苯酚)∶m(PEG 800)∶m(氢氧化钾)∶m(硫酸二甲酯)=1∶0 20∶0 86∶1 29(质量比)。3,4,5 三甲氧基甲苯的收率为92.9%,纯度达98%以上。The reaction conditions for synthesizing 3,4,5-trimethoxy-toluene were optimized with PEG as phase transfer catalyst. The optimized conditions are as follows: reaction temperature is 90℃, reaction time is 2 h, m(2,6-dimethoxy-p-cresol)∶m(PEG-800)∶m(KOH)∶m( (CH_3)_2SO_4)=1∶0.20∶0.86∶1.29, the yield of 3,4,5-trimethoxy-toluene is 92.9%, the purity of 3,4,5-trimethoxy-toluene is 98% upwards.

关 键 词：聚乙二醇 3 4 5-三甲氧基甲苯 相转移催化 

分 类 号：O626.26[理学—有机化学]